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rs6323

From SNPedia

Monoamine oxidase A activity
Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 2.1 Increased monoamine oxidase A activity
(T;T) 3 reduced MAOA activity
Make rs6323(G;T)
ReferenceGRCh38 38.1/141
ChromosomeX
Position43731789
GeneMAOA
is asnp
is mentioned by
dbSNPrs6323
ebirs6323
HLIrs6323
Exacrs6323
Varsomers6323
Maprs6323
PheGenIrs6323
hapmaprs6323
1000 genomesrs6323
hgdprs6323
ensemblrs6323
gopubmedrs6323
geneviewrs6323
scholarrs6323
googlers6323
pharmgkbrs6323
gwascentralrs6323
openSNPrs6323
23andMers6323
23andMe allrs6323
SNP Nexus

SNPshotrs6323
SNPdbers6323
MSV3drs6323
GWAS Ctlgrs6323
GMAF0.3319
Max Magnitude3
? (G;G) (G;T) (T;T) 28
rs6323 (R297R / Arg297Arg) is a SNP in the MAOA (monoamine oxidase A) gene. Monoamine oxidase A degrades serotonin, dopamine, epineprine, and norepinephrine. The G allele encodes for the higher activity form of the enzyme.


[PMID 20691428] A cis-Phase Interaction Study of Genetic Variants Within the MAOA Gene in Major Depressive Disorder

[PMID 19593178] Subjects with major depressive disorder with the highest activity form of the enzyme (G or G/G) had a significantly lower magnitude of placebo response.


[PMID 21978760OA-icon.png] Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese


[PMID 16174289OA-icon.png] MAOA haplotypes associated with thrombocyte-MAO activity.


[PMID 17417058] Monoamine oxidase a gene is associated with borderline personality disorder.


[PMID 18180394OA-icon.png] Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.


[PMID 18501009OA-icon.png] Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese.


[PMID 19693267OA-icon.png] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21216270] Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands.


[PMID 21680027] Influence and interaction of genetic polymorphisms in catecholamine neurotransmitter systems and early life stress on antidepressant drug response.


[PMID 22162429] Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population.


[PMID 23111930] MAOA and MAOB polymorphisms and anger-related traits in suicidal participants and controls


ClinVar
Risk rs6323(T;T)
Alt rs6323(T;T)
Reference rs6323(G;G)
Significance Other
Disease not specified
Variation info
Gene MAOA
CLNDBN not specified
Reversed 0
HGVS NC_000023.10:g.43591036G>T
CLNSRC ClinVar Emory University University of Chicago
CLNACC RCV000078415.7,