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rs6427528

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.5 for rheumatoid arthritis patients, better response to etanercept treatment
(A;G) 1.5 for rheumatoid arthritis patients, better response to etanercept treatment
(G;G) 0 common
ReferenceGRCh38 38.1/141
Chromosome1
Position160546518
GeneCD84
is asnp
is mentioned by
dbSNPrs6427528
ebirs6427528
HLIrs6427528
Exacrs6427528
Varsomers6427528
Maprs6427528
PheGenIrs6427528
hapmaprs6427528
1000 genomesrs6427528
hgdprs6427528
ensemblrs6427528
gopubmedrs6427528
geneviewrs6427528
scholarrs6427528
googlers6427528
pharmgkbrs6427528
gwascentralrs6427528
openSNPrs6427528
23andMers6427528
23andMe allrs6427528
SNP Nexus

SNPshotrs6427528
SNPdbers6427528
MSV3drs6427528
GWAS Ctlgrs6427528
GMAF0.1974
Max Magnitude1.5
rs6427528 is a SNP in the chromosome 1q23 region apparently located near enough to the CD84 locus to affect it's expression.

A GWAS study of 2,700+ rheumatoid arthritis (RA) patients treated with one of three anti-TNF drugs found that rs6427528(A) carriers had higher CD84 expression and responded better to etanercept treatment. The effect was statistically significant but not that large in magnitude, totaling 2.6% of the variance in response to etanercept treatment. The result was seen in European (Caucasian) patients, but perhaps due to small patient numbers, was not statistically supported in Japanese patients.[PMID 23555300OA-icon.png]

? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 23555300OA-icon.png]
Trait Response to anti-TNF treatment in rheumatoid arthritis
Title Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.
Risk Allele A
P-val 2E-6
Odds Ratio NR NR