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rs6458307

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 1.4x risk
(C;T) 0.8x risk
(G;G) 0
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome6
Position42763377
is asnp
is mentioned by
dbSNPrs6458307
ebirs6458307
HLIrs6458307
Exacrs6458307
Varsomers6458307
Maprs6458307
PheGenIrs6458307
hapmaprs6458307
1000 genomesrs6458307
hgdprs6458307
ensemblrs6458307
gopubmedrs6458307
geneviewrs6458307
scholarrs6458307
googlers6458307
pharmgkbrs6458307
gwascentralrs6458307
openSNPrs6458307
23andMers6458307
23andMe allrs6458307
SNP Nexus

SNPshotrs6458307
SNPdbers6458307
MSV3drs6458307
GWAS Ctlgrs6458307
GMAF0.3439
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs6458307 has been reported in a large study to be associated with bipolar disorder.

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 0.84 (CI 0.75-0.96), and for homozygotes, 1.39 (CI 1.13-1.69). [PMID 17554300OA-icon.png]

GWAS
SNP rs6458307
PubMedID [PMID 17554300OA-icon.png]
Condition Bipolar disorder
Gene NR
Risk Allele
pValue 4.00E-006
OR 1.19
95% CI 1.04-1.33



[PMID 19308021OA-icon.png] Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.


GET Evidence
rs6458307
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.453125
summary