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rs6465657

From SNPedia

Influences risk for prostate cancer
Orientationplus
Stabilizedplus
Make rs6465657(C;C)
Make rs6465657(C;T)
Make rs6465657(T;T)
ReferenceGRCh38 38.1/141
Chromosome7
Position98187015
GeneLMTK2
is asnp
is mentioned by
dbSNPrs6465657
ebirs6465657
HLIrs6465657
Exacrs6465657
Varsomers6465657
Maprs6465657
PheGenIrs6465657
hapmaprs6465657
1000 genomesrs6465657
hgdprs6465657
ensemblrs6465657
gopubmedrs6465657
geneviewrs6465657
scholarrs6465657
googlers6465657
pharmgkbrs6465657
gwascentralrs6465657
openSNPrs6465657
23andMers6465657
23andMe allrs6465657
SNP Nexus

SNPshotrs6465657
SNPdbers6465657
MSV3drs6465657
GWAS Ctlgrs6465657
GMAF0.2801
Max Magnitude
? (C;C) (C;T) (T;T) 28
cancer-genetics these snps influence genetic risk for prostate cancer
GWAS
SNP rs6465657
PubMedID [PMID 18264097]
Condition Prostate cancer
Gene LMTK2
Risk Allele C
pValue 1.00E-009
OR 1.12
95% CI 1.05-1.20


[PMID 19336566OA-icon.png] Replication of the 10q11 and Xp11 Prostate Cancer Risk Variants: Results from a Utah Pedigree-Based Study.

OMIM608658
DescPROSTATE CANCER, HEREDITARY, 4
Variant
Relatedalso
OMIM610989
DescLEMUR TYROSINE KINASE 2; LMTK2
Variant
Relatedalso


GWAS snp
PMID [PMID 19767753OA-icon.png]
Trait Prostate cancer
Title Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Risk Allele T
P-val 2E-8
Odds Ratio NR NR


[PMID 20569440OA-icon.png] Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer


[PMID 21820706OA-icon.png] Prostate Cancer Risk Alleles and Their Associations With Other Malignancies


[PMID 18708398OA-icon.png] Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium.


[PMID 18794092OA-icon.png] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.


[PMID 18974127OA-icon.png] Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.


[PMID 19104501OA-icon.png] Prostate cancer genomics: towards a new understanding.


[PMID 19318432OA-icon.png] Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.


[PMID 19366831OA-icon.png] Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features.


[PMID 19434657OA-icon.png] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.


[PMID 19549807OA-icon.png] Prostate cancer risk associated loci in African Americans.


[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.


[PMID 20039378OA-icon.png] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.


[PMID 20450899] Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease.


[PMID 21390317OA-icon.png] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.


[PMID 21538423OA-icon.png] Early onset prostate cancer has a significant genetic component.


GET Evidence
rs6465657
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.399052
summary



[PMID 24411283OA-icon.png] Prostate Cancer (PCa) Risk Variants and Risk of Fatal PCa in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium