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rs6478109

From SNPedia

Orientationplus
Stabilizedplus
Make rs6478109(A;A)
Make rs6478109(A;G)
Make rs6478109(G;G)
ReferenceGRCh38 38.1/141
Chromosome9
Position114806486
GeneTNFSF15
is asnp
is mentioned by
dbSNPrs6478109
ebirs6478109
HLIrs6478109
Exacrs6478109
Varsomers6478109
Maprs6478109
PheGenIrs6478109
hapmaprs6478109
1000 genomesrs6478109
hgdprs6478109
ensemblrs6478109
gopubmedrs6478109
geneviewrs6478109
scholarrs6478109
googlers6478109
pharmgkbrs6478109
gwascentralrs6478109
openSNPrs6478109
23andMers6478109
23andMe allrs6478109
SNP Nexus

SNPshotrs6478109
SNPdbers6478109
MSV3drs6478109
GWAS Ctlgrs6478109
GMAF0.298
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 18758464OA-icon.png]
Trait Inflammatory bowel disease
Title Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
Risk Allele
P-val 2.9999999999999997E-8
Odds Ratio 1.36 [1.22-1.52]
OMIM612259
DescINFLAMMATORY BOWEL DISEASE 16; IBD16
Variant
Relatedalso
[PMID 17663424OA-icon.png] TNFSF15 is an ethnic-specific IBD gene.

[PMID 19262684OA-icon.png] IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.

[PMID 19408013OA-icon.png] Strategies and issues in the detection of pathway enrichment in genome-wide association studies.

[PMID 19543369OA-icon.png] Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritis.

[PMID 22684480] Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFalpha


GET Evidence
rs6478109
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.742188
summary



[PMID 24269700] Genetic risk and protective factors of TNFSF15 gene variants detected using single nucleotide polymorphisms in Hungarians with psoriasis and psoriatic arthritis


[PMID 25028192] Associations between TNFSF15 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: A meta-analysis


[PMID 25501099OA-icon.png] Protective association of tumor necrosis factor superfamily 15 (TNFSF15) polymorphic haplotype with Ulcerative Colitis and Crohn's disease in an Indian population