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rs6494696

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) <0.71x risk for restless legs
(C;G) 0.71x risk for restless legs
(G;G) 0 common
ReferenceGRCh38 38.1/141
Chromosome15
Position67810868
is asnp
is mentioned by
dbSNPrs6494696
ebirs6494696
HLIrs6494696
Exacrs6494696
Varsomers6494696
Maprs6494696
PheGenIrs6494696
hapmaprs6494696
1000 genomesrs6494696
hgdprs6494696
ensemblrs6494696
gopubmedrs6494696
geneviewrs6494696
scholarrs6494696
googlers6494696
pharmgkbrs6494696
gwascentralrs6494696
openSNPrs6494696
23andMers6494696
23andMe allrs6494696
SNP Nexus

SNPshotrs6494696
SNPdbers6494696
MSV3drs6494696
GWAS Ctlgrs6494696
GMAF0.4931
Max Magnitude0
? (C;C) (C;G) (G;G) 28
rs6494696, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (C) minor allele. [PMID 17637780]

The association between this SNP and RLS has been replicated in three European populations.[PMID 19279021OA-icon.png]

OMIM102300
DescRESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 1
Variant
Relatedalso



GET Evidence
rs6494696
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.46875
summary



[PMID 25142570OA-icon.png] Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD