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rs6495446

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1 normal, but increased risk for chronic kidney disease
(C;T) 1.4 0.8x reduced risk for chronic kidney disease
(T;T) 2 0.64x reduced risk for chronic kidney disease
ReferenceGRCh38 38.1/141
Chromosome15
Position79862640
GeneMTHFS, ST20-MTHFS
is asnp
is mentioned by
dbSNPrs6495446
ebirs6495446
HLIrs6495446
Exacrs6495446
Varsomers6495446
Maprs6495446
PheGenIrs6495446
hapmaprs6495446
1000 genomesrs6495446
hgdprs6495446
ensemblrs6495446
gopubmedrs6495446
geneviewrs6495446
scholarrs6495446
googlers6495446
pharmgkbrs6495446
gwascentralrs6495446
openSNPrs6495446
23andMers6495446
23andMe allrs6495446
SNP Nexus

SNPshotrs6495446
SNPdbers6495446
MSV3drs6495446
GWAS Ctlgrs6495446
GMAF0.3058
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs6495446, an intronic SNP in the MTHFS gene, was associated with increased risk for chronic kidney disease based on a study associated with the Framingham Heart Study of ~1,000 Caucasian individuals. The odds ratio rs6495446(C) allele was 1.24 (CI: 1.09-1.41, p=0.001).news 23andMe reports this same information with a different emphasis: each T allele lowers the odds of chronic kidney disease by 0.8 times. [PMID 18522750OA-icon.png]


[PMID 21895484] The impact of 5,10-methenyltetrahydrofolate synthetase polymorphism on diabetic nephropathy in the Taiwanese population.