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rs650108

From SNPedia

Orientationplus
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Geno Mag Summary
(A;A) 1 higher risk for Achilles tendinopathy?
Make rs650108(A;G)
Make rs650108(G;G)
ReferenceGRCh38 38.1/141
Chromosome11
Position102838056
GeneMMP3
is asnp
is mentioned by
dbSNPrs650108
ebirs650108
HLIrs650108
Exacrs650108
Varsomers650108
Maprs650108
PheGenIrs650108
hapmaprs650108
1000 genomesrs650108
hgdprs650108
ensemblrs650108
gopubmedrs650108
geneviewrs650108
scholarrs650108
googlers650108
pharmgkbrs650108
gwascentralrs650108
openSNPrs650108
23andMers650108
23andMe allrs650108
SNP Nexus

SNPshotrs650108
SNPdbers650108
MSV3drs650108
GWAS Ctlgrs650108
GMAF0.4118
Max Magnitude1
rs650108 is a SNP in the matrix metallopeptidase 3 MMP3 gene on ch 11.

[PMID 19042922] A relatively small study (~100 patients) found associations between risk for Achilles tendinopathy and SNPs in the MMP3 gene. For rs650108, the (A;A) genotype had an odds ratio of 4.9 (CI: 1.0 to 24.1, p = 0.043).

? (A;A) (A;G) (G;G) 28

[PMID 19762026] Haplotypes and 5A/6A polymorphism of the matrix metalloproteinase-3 gene in coronary disease: Case-control study and a meta-analysis



[PMID 21134112OA-icon.png] Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis


[PMID 19318431OA-icon.png] No association between matrix metalloproteinase-1 or matrix metalloproteinase-3 polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study.


[PMID 19435861OA-icon.png] No association between matrix metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and endometrial cancer risk.


GET Evidence
rs650108
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.367188
summary



[PMID 22671570OA-icon.png] MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression.


[PMID 26191285OA-icon.png] Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair