rs650108

plus

Geno	Mag	Summary
(A;A)	1	higher risk for Achilles tendinopathy?

Make rs650108(A;G)

Make rs650108(G;G)

Reference

GRCh38 38.1/141

Chromosome

11

Position

102838056

Gene

MMP3

is a	snp
is	mentioned by
dbSNP	rs650108
dbSNP (classic)	rs650108
ClinGen	rs650108
ebi	rs650108
HLI	rs650108
Exac	rs650108
Gnomad	rs650108
Varsome	rs650108
LitVar	rs650108
Map	rs650108
PheGenI	rs650108
Biobank	rs650108
1000 genomes	rs650108
hgdp	rs650108
ensembl	rs650108
geneview	rs650108
scholar	rs650108
google	rs650108
pharmgkb	rs650108
gwascentral	rs650108
openSNP	rs650108
23andMe	rs650108
SNPshot	rs650108
SNPdbe	rs650108
MSV3d	rs650108
GWAS Ctlg	rs650108

GMAF

0.4118

Max Magnitude

1

rs650108 is a SNP in the matrix metallopeptidase 3 MMP3 gene on ch 11.

[PMID 19042922] A relatively small study (~100 patients) found associations between risk for Achilles tendinopathy and SNPs in the MMP3 gene. For rs650108, the (A;A) genotype had an odds ratio of 4.9 (CI: 1.0 to 24.1, p = 0.043).

?

(A;A) (A;G) (G;G)

28

[PMID 19762026] Haplotypes and 5A/6A polymorphism of the matrix metalloproteinase-3 gene in coronary disease: Case-control study and a meta-analysis

[PMID 21134112 ] Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis

[PMID 19318431 ] No association between matrix metalloproteinase-1 or matrix metalloproteinase-3 polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study.

[PMID 19435861 ] No association between matrix metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and endometrial cancer risk.

[PMID 22671570 ] MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression.

[PMID 26191285 ] Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair

[PMID 32607795] Association of the matrix metalloproteinase 3 (MMP3) single nucleotide polymorphisms with tendinopathies: case-control study in high-level athletes.