Have questions? Visit https://www.reddit.com/r/SNPedia

rs6505162

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.1 0.43x decreased risk for esophageal cancer
(A;C) 2 0.58x decreased risk for esophageal cancer
(C;C) 1.5 normal
ReferenceGRCh38 38.1/141
Chromosome17
Position30117165
GeneNSRP1
is asnp
is mentioned by
dbSNPrs6505162
ebirs6505162
HLIrs6505162
Exacrs6505162
Varsomers6505162
Maprs6505162
PheGenIrs6505162
hapmaprs6505162
1000 genomesrs6505162
hgdprs6505162
ensemblrs6505162
gopubmedrs6505162
geneviewrs6505162
scholarrs6505162
googlers6505162
pharmgkbrs6505162
gwascentralrs6505162
openSNPrs6505162
23andMers6505162
23andMe allrs6505162
SNP Nexus

SNPshotrs6505162
SNPdbers6505162
MSV3drs6505162
GWAS Ctlgrs6505162
GMAF0.4885
Max Magnitude2.1
? (A;A) (A;C) (C;C) 28
rs6505162 is a SNP located in the pre-miRNA region of mir423. The major allele is rs6505162(C).

A study of 346 Caucasians with esophageal cancer found that compared with the homozygous wild-type genotype of rs6505162, individuals with the heterozygous and homozygous variant genotype had a significantly reduced esophageal cancer risk with odds ratios of 0.58 (CI: 0.41-0.82) and 0.43 (CI: 0.27-0.68), respectively. After stratifying by gender, smoking, and age, the authors discovered that the protective effect was significant only for individuals under 64 years of age, regardless of sex or whether they smoked. Other unfavorable genotypes (ie SNPs) were also identified that were not as significant as rs6505162, and the overall risk of esophageal cancer increased with increasing numbers of unfavorable SNPs.10.1158/1940-6207.CAPR-08-0135 [PMID 19138993OA-icon.png]

snp near microRNA
ACC MI0001445
ID hsa-mir-423
offset -39


discussed in nature


[PMID 19950226] SNPs in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high risk women


[PMID 22028396OA-icon.png] Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer


[PMID 22593246] A Genetic Variant Located in miR-423 is Associated with Reduced Breast Cancer Risk


[PMID 18521189OA-icon.png] Genetic variants of miRNA sequences and non-small cell lung cancer survival.


[PMID 19047128OA-icon.png] Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.


[PMID 19458495OA-icon.png] Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.


[PMID 22818121] The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer


[PMID 24205249OA-icon.png] MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell Carcinoma


[PMID 24413317] MicroRNA sequence polymorphisms and the risk of different types of cancer


[PMID 24854593OA-icon.png] Identification of miR-423 and miR-499 Polymorphisms on Affecting the Risk of Hepatocellular Carcinoma in a Large-Scale Population


[PMID 25663458] Genetic analysis and preliminary function study of miR-423 in breast cancer


[PMID 25901206OA-icon.png] Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease


[PMID 25926693] The polymorphism of rs6505162 in miR-423 coding region and recurrent pregnancy loss


[PMID 26518769] Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population


[PMID 27421647] Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population.