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rs6539137

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) increased risk for and earlier onset in males of familial ALS
(A;T)
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome12
Position104313402
GeneTXNRD1
is asnp
is mentioned by
dbSNPrs6539137
ebirs6539137
HLIrs6539137
Exacrs6539137
Varsomers6539137
Maprs6539137
PheGenIrs6539137
hapmaprs6539137
1000 genomesrs6539137
hgdprs6539137
ensemblrs6539137
gopubmedrs6539137
geneviewrs6539137
scholarrs6539137
googlers6539137
pharmgkbrs6539137
gwascentralrs6539137
openSNPrs6539137
23andMers6539137
23andMe allrs6539137
SNP Nexus

SNPshotrs6539137
SNPdbers6539137
MSV3drs6539137
GWAS Ctlgrs6539137
GMAF0.0528
Max Magnitude0
? (A;A) (A;T) (T;T) 28
[PMID 18996185] rs6539137 is one of several TXNRD1 SNPs significantly associated with familial amyotrophic lateral sclerosis (FALS) but not sporadic amyotrophic lateral sclerosis (ALS). The risk allele, rs6539137(A), is also associated with an earlier age of onset by 8 years, and the shift was more significant in males (in fact, insignificant in females).