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rs6548238

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
Make rs6548238(C;T)
Make rs6548238(T;T)
ReferenceGRCh37 37.1/131
Chromosome2
Position634905
is asnp
is mentioned by
dbSNPrs6548238
ebirs6548238
HLIrs6548238
Exacrs6548238
Varsomers6548238
Maprs6548238
PheGenIrs6548238
hapmaprs6548238
1000 genomesrs6548238
hgdprs6548238
ensemblrs6548238
gopubmedrs6548238
geneviewrs6548238
scholarrs6548238
googlers6548238
pharmgkbrs6548238
gwascentralrs6548238
openSNPrs6548238
23andMers6548238
23andMe allrs6548238
SNP Nexus

SNPshotrs6548238
SNPdbers6548238
MSV3drs6548238
GWAS Ctlgrs6548238
GMAF0.1281
Max Magnitude0
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19079261OA-icon.png]
Trait Body mass index
Title Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Risk Allele C
P-val 1E-18
Odds Ratio 0.26 [0.19-0.34] kg/m2 increase


[PMID 19851340] Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population


OMIM613220
DescTRANSMEMBRANE PROTEIN 18; TMEM18
Variant
Relatedalso
[PMID 20386550OA-icon.png] Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA

[PMID 20380707OA-icon.png] The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children


[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area


[PMID 22083549] Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty


[PMID 19164386OA-icon.png] Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.


[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?


[PMID 19553259OA-icon.png] Common body mass index-associated variants confer risk of extreme obesity.


[PMID 19910938] Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.


[PMID 20127379OA-icon.png] From monogenic to polygenic obesity: recent advances.


[PMID 20520848OA-icon.png] Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.


[PMID 20628085OA-icon.png] First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study.


[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.


[PMID 20725061OA-icon.png] MC4R variant is associated with BMI but not response to resistance training in young females.


[PMID 20824172OA-icon.png] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.


[PMID 21283731OA-icon.png] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.


[PMID 21593506OA-icon.png] Maternal and offspring adiposity-related genetic variants and gestational weight gain.


[PMID 21952719OA-icon.png] Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats.


[PMID 22179955OA-icon.png] Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.


[PMID 22466342] beta2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.


GET Evidence
rs6548238
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.912698
summary



Obesity: Preliminary Research

Measures of Obesity


[PMID 23311614OA-icon.png] Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study


[PMID 23775818] Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study.


[PMID 24762112] Increased body mass index, elevated C-reactive protein, and short telomere length


[PMID 27650258] A multianalytical approach to evaluate the association of 55 SNPs in 28 genes with obesity risk in North Indian adults.


[PMID 27829468] Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children.