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rs657152

From SNPedia

Orientationminus
Stabilizedplus
Geno Mag Summary
(T;T) 2 Multiple risks, see details
Make rs657152(G;G)
Make rs657152(G;T)
ReferenceGRCh38 38.1/142
Chromosome9
Position133263862
GeneABO
is asnp
is mentioned by
dbSNPrs657152
ebirs657152
HLIrs657152
Exacrs657152
Varsomers657152
Maprs657152
PheGenIrs657152
hapmaprs657152
1000 genomesrs657152
hgdprs657152
ensemblrs657152
gopubmedrs657152
geneviewrs657152
scholarrs657152
googlers657152
pharmgkbrs657152
gwascentralrs657152
openSNPrs657152
23andMers657152
23andMe allrs657152
SNP Nexus

SNPshotrs657152
SNPdbers657152
MSV3drs657152
GWAS Ctlgrs657152
GMAF0.3842
Max Magnitude2
? (G;G) (G;T) (T;T) 28
GWAS snp
PMID [PMID 18940312OA-icon.png]
Trait Plasma levels of liver enzymes
Title Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
Risk Allele T
P-val 2E-30
Odds Ratio 0.05 [0.039-0.055] U/L decrease

The T allele of this SNP is associated with higher risk of pancreatic cancer. [PMID 19648918OA-icon.png]

OMIM171720
DescALKALINE PHOSPHATASE, PLASMA LEVEL OF, QUANTITATIVE TRAIT LOCUS 1
Variant
Relatedalso



[PMID 20529992] Genetic Regulation of Serum Phytosterol Levels and Risk of Coronary Artery Disease

[PMID 18514160OA-icon.png] Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.

[PMID 18604267OA-icon.png] Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.

[PMID 19474294OA-icon.png] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

[PMID 19729612OA-icon.png] Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.

[PMID 21534939] Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip.


GET Evidence
rs657152
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.375
summary



GWAS snp
PMID [PMID 23408906OA-icon.png]
Trait Thyroid hormone levels
Title A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
Risk Allele A
P-val 4E-10
Odds Ratio .06 [0.04-0.076] unit increase


[PMID 23707316] High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-analysis


[PMID 23816557OA-icon.png] Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population.

GWAS snp
PMID [PMID 24586186OA-icon.png]
Trait Urinary metabolites (H-NMR features)
Title Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.
Risk Allele C
P-val 1E-19
Odds Ratio .34 [NR] unit increase
GWAS snp
PMID [PMID 24094242OA-icon.png]
Trait Serum alkaline phosphatase levels
Title Genome-wide association study on serum alkaline phosphatase levels in a Chinese population.
Risk Allele T
P-val 4E-8
Odds Ratio .06 [NR] U/L decrease
GWAS snp
PMID [PMID 23251661OA-icon.png]
Trait Obesity-related traits
Title Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Risk Allele A
P-val 2E-8
Odds Ratio .04 [NR] pg/mL increase


[PMID 26286125] Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study