rs657152

minus

Geno	Mag	Summary
(G;G)	0	common/normal
(T;T)	2	A few different minor risk associations; see details

Make rs657152(G;T)

Reference

GRCh38 38.1/142

Chromosome

9

Position

133263862

Gene

ABO

is a	snp
is	mentioned by
dbSNP	rs657152
dbSNP (classic)	rs657152
ClinGen	rs657152
ebi	rs657152
HLI	rs657152
Exac	rs657152
Gnomad	rs657152
Varsome	rs657152
LitVar	rs657152
Map	rs657152
PheGenI	rs657152
Biobank	rs657152
1000 genomes	rs657152
hgdp	rs657152
ensembl	rs657152
geneview	rs657152
scholar	rs657152
google	rs657152
pharmgkb	rs657152
gwascentral	rs657152
openSNP	rs657152
23andMe	rs657152
SNPshot	rs657152
SNPdbe	rs657152
MSV3d	rs657152
GWAS Ctlg	rs657152

GMAF

0.3842

Max Magnitude

2

?

(G;G) (G;T) (T;T)

28

GWAS snp
PMID	[PMID 18940312 ]
Trait	Plasma levels of liver enzymes
Title	Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
Risk Allele	T
P-val	2E-30
Odds Ratio	0.05 [0.039-0.055] U/L decrease

The T allele of this SNP is associated with very slightly higher risk of pancreatic cancer. [PMID 19648918 ]

OMIM	171720
Desc	ALKALINE PHOSPHATASE, PLASMA LEVEL OF, QUANTITATIVE TRAIT LOCUS 1
Variant
Related	also

[PMID 20529992] Genetic Regulation of Serum Phytosterol Levels and Risk of Coronary Artery Disease

[PMID 18514160 ] Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.

[PMID 18604267 ] Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.

[PMID 19474294 ] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

[PMID 19729612 ] Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.

[PMID 21534939] Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip.

GWAS snp
PMID	[PMID 23408906 ]
Trait	Thyroid hormone levels
Title	A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
Risk Allele	A
P-val	4E-10
Odds Ratio	.06 [0.04-0.076] unit increase

[PMID 23707316] High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-analysis

[PMID 23816557 ] Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population.

GWAS snp
PMID	[PMID 24586186 ]
Trait	Urinary metabolites (H-NMR features)
Title	Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.
Risk Allele	C
P-val	1E-19
Odds Ratio	.34 [NR] unit increase

GWAS snp
PMID	[PMID 24094242 ]
Trait	Serum alkaline phosphatase levels
Title	Genome-wide association study on serum alkaline phosphatase levels in a Chinese population.
Risk Allele	T
P-val	4E-8
Odds Ratio	.06 [NR] U/L decrease

GWAS snp
PMID	[PMID 23251661 ]
Trait	Obesity-related traits
Title	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Risk Allele	A
P-val	2E-8
Odds Ratio	.04 [NR] pg/mL increase

[PMID 26286125 ] Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study