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rs6584400

From SNPedia

Orientationplus
Stabilizedplus
Make rs6584400(A;A)
Make rs6584400(A;G)
Make rs6584400(G;G)
ReferenceGRCh38 38.1/142
Chromosome10
Position81896770
GeneNRG3
is asnp
is mentioned by
dbSNPrs6584400
ebirs6584400
HLIrs6584400
Exacrs6584400
Varsomers6584400
Maprs6584400
PheGenIrs6584400
hapmaprs6584400
1000 genomesrs6584400
hgdprs6584400
ensemblrs6584400
gopubmedrs6584400
geneviewrs6584400
scholarrs6584400
googlers6584400
pharmgkbrs6584400
gwascentralrs6584400
openSNPrs6584400
23andMers6584400
23andMe allrs6584400
SNP Nexus

SNPshotrs6584400
SNPdbers6584400
MSV3drs6584400
GWAS Ctlgrs6584400
GMAF0.225
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs6584400 is a SNP in the neuregulin 3 NRG3 gene.

Based on a study of 1515 Ashkenazi Jewish individuals, including 285 parent-child trios, 173 unrelated cases, and 487 unrelated controls, three SNPs (rs10883866, rs10748842, and rs6584400) were found to be associated with the "delusion" factor as a quantitative trait in schizophrenia, even though no SNP in this study withstood multiple test correction for association with the binary schizophrenia phenotype itself. After replication in an independent set of 153 Ashkenazi Jewish samples, the empirical study-wide significance across all 9 factors studied was estimated to be p = 2.7x10e-3.[PMID 19118813OA-icon.png]



[PMID 20713722OA-icon.png] Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain


[PMID 22831755] Neuregulin 3 is associated with attention deficits in schizophrenia and bipolar disorder


[PMID 20548296] Neuregulin 3 (NRG3) as a susceptibility gene in a schizophrenia subtype with florid delusions and relatively spared cognition.


GET Evidence
rs6584400
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.320312
summary