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rs660339

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 common in clinvar
Make rs660339(C;T)
Make rs660339(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position73978059
GeneUCP2
is asnp
is mentioned by
dbSNPrs660339
ebirs660339
HLIrs660339
Exacrs660339
Varsomers660339
Maprs660339
PheGenIrs660339
hapmaprs660339
1000 genomesrs660339
hgdprs660339
ensemblrs660339
gopubmedrs660339
geneviewrs660339
scholarrs660339
googlers660339
pharmgkbrs660339
gwascentralrs660339
openSNPrs660339
23andMers660339
23andMe allrs660339
SNP Nexus

SNPshotrs660339
SNPdbers660339
MSV3drs660339
GWAS Ctlgrs660339
GMAF0.4316
Max Magnitude0
? (C;C) (C;T) (T;T) 28

[PMID 19833146] Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain

[PMID 17066476] Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.

[PMID 17601350OA-icon.png] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

[PMID 17894153] Ala55Val polymorphism on UCP2 gene predicts greater weight loss in morbidly obese patients undergoing gastric banding.

[PMID 18496642OA-icon.png] Lack of association between uncoupling protein-2 Ala55Val polymorphism and incident diabetes in the atherosclerosis risk in communities study.

[PMID 18599530OA-icon.png] Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients.

[PMID 18956255] Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese.

[PMID 18996102] Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.

[PMID 19681913] Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus.

[PMID 19760975] Prediction of successful weight reduction after laparoscopic adjustable gastric banding.

[PMID 19769793OA-icon.png] Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.

[PMID 20142250OA-icon.png] Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study.

[PMID 21720911] ESR1, FTO, and UCP2 genes interact with bariatric surgery affecting weight loss and glycemic control in severely obese patients.

[PMID 21883184] Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population.


GET Evidence
UCP2-A55V
aa_change Ala55Val
aa_change_short A55V
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.42071
summary



[PMID 22533685OA-icon.png] Uncoupling protein 2 gene polymorphisms are associated with obesity


[PMID 23681449] Genes for Elite Power and Sprint Performance: ACTN3 Leads the Way


[PMID 25396419OA-icon.png] Investigation of Variants in UCP2 in Chinese Type 2 Diabetes and Diabetic Retinopathy


ClinVar
Risk rs660339(T;T)
Alt rs660339(T;T)
Reference rs660339(C;C)
Significance Probable-non-pathogenic
Disease not specified
Variation info
Gene UCP2
CLNDBN not specified
Reversed 1
HGVS NC_000011.9:g.73689104G>A
CLNSRC ClinVar University of Chicago
CLNACC RCV000118811.2,



[PMID 27615599] Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes.