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rs661

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 9 early onset Alzheimer's disease
(A;G) 9 early-onset Alzheimers disease
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome14
Position73217225
GenePSEN1
is asnp
is mentioned by
dbSNPrs661
ebirs661
HLIrs661
Exacrs661
Varsomers661
Maprs661
PheGenIrs661
hapmaprs661
1000 genomesrs661
hgdprs661
ensemblrs661
gopubmedrs661
geneviewrs661
scholarrs661
googlers661
pharmgkbrs661
gwascentralrs661
openSNPrs661
23andMers661
23andMe allrs661
SNP Nexus

SNPshotrs661
SNPdbers661
MSV3drs661
GWAS Ctlgrs661
Max Magnitude9

rs661, also known as C410Y or Cys410Tyr, is a SNP in the presenilin 1 PSEN1 gene.

The rare rs661(A) allele is considered causative for early-onset Alzheimer's disease.[PMID 7596406]

OMIM104311
DescALZHEIMER DISEASE, FAMILIAL, 3
Variant0005
Relatedalso
ClinVar
Risk rs661(A,T;A,T)
Alt rs661(A,T;A,T)
Reference rs661(G;G)
Significance Pathogenic
Disease Alzheimer disease not provided
Variation info
Gene PSEN1
CLNDBN Alzheimer disease, type 3 not provided
Reversed 0
HGVS NC_000014.8:g.73683933G>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000019755.27, RCV000084407.1,