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rs668

From SNPedia

Merged intors281865545
Orientationminus
Stabilizedplus
Make rs668(C;C)
Make rs668(C;G)
Make rs668(G;G)
ReferenceGRCh38 38.1/142
Chromosome17
Position64377836
GenePECAM1
is asnp
is mentioned by
dbSNPrs668
ebirs668
HLIrs668
Exacrs668
Varsomers668
Maprs668
PheGenIrs668
hapmaprs668
1000 genomesrs668
hgdprs668
ensemblrs668
gopubmedrs668
geneviewrs668
scholarrs668
googlers668
pharmgkbrs668
gwascentralrs668
openSNPrs668
23andMers668
23andMe allrs668
SNP Nexus

SNPshotrs668
SNPdbers668
MSV3drs668
GWAS Ctlgrs668
StatusMerged into rs281865545
Merged fromRs28933978
Max Magnitude
? (C;C) (C;G) (G;G) 28

7thspace the G allele was a risk factor for malaria in the endemic region, but exhibited significant association with protection from disease in the non-endemic region.


[PMID 19055786OA-icon.png] Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.


[PMID 19406964OA-icon.png] Association of genetic variants with chronic kidney disease in Japanese individuals.


[PMID 20031567OA-icon.png] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.


[PMID 21155722] Minor histocompatibility antigens in Tunisians: could platelet endothelial cell adhesion molecule 1 marker be one of them?


GET Evidence
PECAM1-L125V
aa_change Leu125Val
aa_change_short L125V
impact pharmacogenetic
qualified_impact Low clinical importance, Likely pharmacogenetic
overall_frequency 0.570312
summary Mismatched genotypes in this variant between donor and recipient is associated with causing graft vs. host disease in bone marrow transplants.



[PMID 23906939] Association of single nucleotide polymorphisms in the gene encoding platelet endothelial cell adhesion molecule-1 with the risk of myocardial infarction: a systematic review and meta-analysis


[PMID 23906684] Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants


[PMID 22646485OA-icon.png] Association between genetic variants in adhesion molecules and outcomes after hematopoietic cell transplants


[PMID 26662939] Genotype/allelic combinations as potential predictors of myocardial infarction.


[PMID 26884965] Association of susceptibility to septic shock with platelet endothelial cell adhesion molecule-1 gene Leu125Val polymorphism and serum sPECAM-1 levels in sepsis patients.