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rs6682654

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0
(A;G) 1.34x increased risk for rheumatoid arthritis
(G;G) 1.8x increased risk for rheumatoid arthritis
ReferenceGRCh38 38.1/141
Chromosome1
Position160839213
GeneCD244
is asnp
is mentioned by
dbSNPrs6682654
ebirs6682654
HLIrs6682654
Exacrs6682654
Varsomers6682654
Maprs6682654
PheGenIrs6682654
hapmaprs6682654
1000 genomesrs6682654
hgdprs6682654
ensemblrs6682654
gopubmedrs6682654
geneviewrs6682654
scholarrs6682654
googlers6682654
pharmgkbrs6682654
gwascentralrs6682654
openSNPrs6682654
23andMers6682654
23andMe allrs6682654
SNP Nexus

SNPshotrs6682654
SNPdbers6682654
MSV3drs6682654
GWAS Ctlgrs6682654
GMAF0.4256
Max Magnitude0
? (A;A) (A;G) (G;G) 28
Two SNPs on ch 1q in the CD244 gene, rs3766379 and rs6682654, were found to be associated with risk for rheumatoid arthritis in two independent Japanese cohorts (p = 3.23 x 10e-8) and p = 7.45 x 10e-8). The odds ratio reported for the more common rs6682654(G) allele, as oriented in dbSNP and not the publication, was 1.34 (CI: 1.15-1.55, p = 0.0002).[PMID 18794858]
OMIM180300
DescRHEUMATOID ARTHRITIS; RA
Variant
Relatedalso
[PMID 19435719OA-icon.png] Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study.


[PMID 20437071] Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus.