rs6682654

plus

Geno	Mag	Summary
(A;A)	0
(A;G)		1.34x increased risk for rheumatoid arthritis
(G;G)		1.8x increased risk for rheumatoid arthritis

Reference

GRCh38 38.1/141

Chromosome

1

Position

160839213

Gene

CD244

is a	snp
is	mentioned by
dbSNP	rs6682654
dbSNP (classic)	rs6682654
ClinGen	rs6682654
ebi	rs6682654
HLI	rs6682654
Exac	rs6682654
Gnomad	rs6682654
Varsome	rs6682654
LitVar	rs6682654
Map	rs6682654
PheGenI	rs6682654
Biobank	rs6682654
1000 genomes	rs6682654
hgdp	rs6682654
ensembl	rs6682654
geneview	rs6682654
scholar	rs6682654
google	rs6682654
pharmgkb	rs6682654
gwascentral	rs6682654
openSNP	rs6682654
23andMe	rs6682654
SNPshot	rs6682654
SNPdbe	rs6682654
MSV3d	rs6682654
GWAS Ctlg	rs6682654

GMAF

0.4256

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

Two SNPs on ch 1q in the CD244 gene, rs3766379 and rs6682654, were found to be associated with risk for rheumatoid arthritis in two independent Japanese cohorts (p = 3.23 x 10e-8) and p = 7.45 x 10e-8). The odds ratio reported for the more common rs6682654(G) allele, as oriented in dbSNP and not the publication, was 1.34 (CI: 1.15-1.55, p = 0.0002).[PMID 18794858]

OMIM	180300
Desc	RHEUMATOID ARTHRITIS; RA
Variant
Related	also

[PMID 19435719 ] Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study.

[PMID 20437071] Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus.