|?|| (C;C) (C;T) (T;T) ||28|
A study of 219 female melanoma
patients and an equal number of controls concluded that 4 linked SNPs within the IL6R
gene were associated with increased melanoma
risk, but only when heterozygous. [Note that there may have been too few minor allele homozygotes to study, though.] The odds ratio associated with the minor allele of this SNP, rs6684439
, was 1.74 (CI: 1.07-2.81). The 4 linked SNPs from identified in this study are: rs6684439
, and rs8192284
[PMID 18852330] Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.
[PMID 19124510] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.
[PMID 20031577] Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.