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rs6684439

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) normal
(C;T) 1.7x increased melanoma risk
(T;T) normal?
ReferenceGRCh38 38.1/141
Chromosome1
Position154423363
GeneIL6R
is asnp
is mentioned by
dbSNPrs6684439
ebirs6684439
HLIrs6684439
Exacrs6684439
Varsomers6684439
Maprs6684439
PheGenIrs6684439
hapmaprs6684439
1000 genomesrs6684439
hgdprs6684439
ensemblrs6684439
gopubmedrs6684439
geneviewrs6684439
scholarrs6684439
googlers6684439
pharmgkbrs6684439
gwascentralrs6684439
openSNPrs6684439
23andMers6684439
23andMe allrs6684439
SNP Nexus

SNPshotrs6684439
SNPdbers6684439
MSV3drs6684439
GWAS Ctlgrs6684439
GMAF0.3815
Max Magnitude
? (C;C) (C;T) (T;T) 28
A study of 219 female melanoma patients and an equal number of controls concluded that 4 linked SNPs within the IL6R gene were associated with increased melanoma risk, but only when heterozygous. [Note that there may have been too few minor allele homozygotes to study, though.] The odds ratio associated with the minor allele of this SNP, rs6684439, was 1.74 (CI: 1.07-2.81). The 4 linked SNPs from identified in this study are: rs6684439, rs4845618, rs4845622, and rs8192284.[PMID 18781131OA-icon.png]


[PMID 18852330OA-icon.png] Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.


[PMID 19124510OA-icon.png] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.


[PMID 20031577OA-icon.png] Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.