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rs6700125

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1.4 0.7x decreased risk for ALS
(C;T) 1.8 1.2x increased risk for ALS
(T;T) 2 1.76x increased risk for ALS
ReferenceGRCh38 38.1/141
Chromosome1
Position59237125
is asnp
is mentioned by
dbSNPrs6700125
ebirs6700125
HLIrs6700125
Exacrs6700125
Varsomers6700125
Maprs6700125
PheGenIrs6700125
hapmaprs6700125
1000 genomesrs6700125
hgdprs6700125
ensemblrs6700125
gopubmedrs6700125
geneviewrs6700125
scholarrs6700125
googlers6700125
pharmgkbrs6700125
gwascentralrs6700125
openSNPrs6700125
23andMers6700125
23andMe allrs6700125
SNP Nexus

SNPshotrs6700125
SNPdbers6700125
MSV3drs6700125
GWAS Ctlgrs6700125
GMAF0.444
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs6700125 is one of 6 SNPs found upstream of an (uncharacterized) gene known as FLJ10986 that have been found to be overrepresented in patients with sporadic amyotrophic lateral sclerosis (ALS).

A genome-wide association study of 1,152 ALS patients determined an allelic odds ratio of 1.38 for the rs6700125(T) allele (CI: 1.16-1.65, p=0.00032). The genotypic odds ratio presented were 1.76 (CI: 1.22-2.55) and 1.2 (CI: 0.83-1.73) for homozygotes and heterozygotes, respectively.[PMID 17671248]

  • Note: this SNP is in strong linkage disequilibrium with rs6690993 (r2>0.8)

[PMID 19177248] A study involving a large case-control series from the Netherlands, Belgium, Sweden and Ireland (total: 1883 sporadic ALS patients and 2063 controls) found no significant association between sporadic ALS and the six previously reported associated SNPs, including this one.


[PMID 19922138] Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis


[PMID 19193627OA-icon.png] A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.


[PMID 22795786] No association of five candidate genetic variants with amyotrophic lateral sclerosis in a Chinese population


[PMID 24439956] The single-nucleotide polymorphism rs6690993 in FGGY is not associated with amyotrophic lateral sclerosisin a large Chinese cohort