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rs6710341

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1 Normal risk of developing restless legs syndrome
(A;G) 1.5 Slightly increased risk of developing restless legs syndrome
(G;G) 2 Increased risk of developing restless legs syndrome
ReferenceGRCh38 38.1/141
Chromosome2
Position66531290
GeneMEIS1
is asnp
is mentioned by
dbSNPrs6710341
ebirs6710341
HLIrs6710341
Exacrs6710341
Varsomers6710341
Maprs6710341
PheGenIrs6710341
hapmaprs6710341
1000 genomesrs6710341
hgdprs6710341
ensemblrs6710341
gopubmedrs6710341
geneviewrs6710341
scholarrs6710341
googlers6710341
pharmgkbrs6710341
gwascentralrs6710341
openSNPrs6710341
23andMers6710341
23andMe allrs6710341
SNP Nexus

SNPshotrs6710341
SNPdbers6710341
MSV3drs6710341
GWAS Ctlgrs6710341
GMAF0.1915
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs6710341, a SNP located in the MEIS1 gene, has been linked to restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.96 (CI: 0.77-1.17) for the (G) risk allele. [PMID 17637780]

The association from this region that gives the highest association to restless legs syndrome, however, is a haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41). [PMID 17637780]


[PMID 19223043] Exploring the genetic link between RLS and ADHD


[PMID 19279021OA-icon.png] Replication of restless legs syndrome loci in three European populations.