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rs6733839

From SNPedia

Orientationplus
Stabilizedplus
Make rs6733839(C;C)
Make rs6733839(C;T)
Make rs6733839(T;T)
ReferenceGRCh38 38.1/141
Chromosome2
Position127135234
is asnp
is mentioned by
dbSNPrs6733839
ebirs6733839
HLIrs6733839
Exacrs6733839
Varsomers6733839
Maprs6733839
PheGenIrs6733839
hapmaprs6733839
1000 genomesrs6733839
hgdprs6733839
ensemblrs6733839
gopubmedrs6733839
geneviewrs6733839
scholarrs6733839
googlers6733839
pharmgkbrs6733839
gwascentralrs6733839
openSNPrs6733839
23andMers6733839
23andMe allrs6733839
SNP Nexus

SNPshotrs6733839
SNPdbers6733839
MSV3drs6733839
GWAS Ctlgrs6733839
Max Magnitude
rs6733839 is a SNP in the bridging integrator 1 BIN1 gene.

BIN1 is a well established risk gene for Alzheimer's disease which was recently confirmed in the International Genomics of Alzheimer's Project (IGAP) study.

This SNP has a population attributable fraction for AD of 8.1 which is second only to APOE4's of 27.3. The minor allele T is the risk allele with an associated odds ratio of 1.22 (1.18–1.25) and P-value = 7 x 10^^-44. http://www.genome.gov/GWASStudySNPS.cfm?id=7523

rs6733839 and rs744373 are less than 2,000 base pairs apart,and they have similar ORs and MAFs. Therefore, it seems reasonable to suspect that these 2 SNPs are actually reporting the same signal.

rs744373 rs6733839 1805 0.580 0.909 None chr2 127609280

This line is taken from the SNAP file for rs744373 http://www.broadinstitute.org/mpg/snap/ldsearch.php . The first two entries identify the SNPs, then the base pair distance between them, their r^^2, DPrime, arrays present on, chromosome number, and the location.

[PMID 24443964OA-icon.png] Review: The genetics of Alzheimer's disease; putting flesh on the bones

GWAS snp
PMID [PMID 24162737OA-icon.png]
Trait Alzheimer's disease (late onset)
Title Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
Risk Allele T
P-val 7E-44
Odds Ratio 1.22 [1.18-1.25]

[PMID 26947052] Potential contribution of the Alzheimer׳s disease risk locus BIN1 to episodic memory performance in cognitively normal Type 2 diabetes elderly.