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rs67666821

From SNPedia

CYP3A4 variant affecting acetaminophen, codeine and other medicines
Orientationplus
Stabilizedplus
Geno Mag Summary
(-;-) 0 common in complete genomics
(-;T) 2.5 CYP3A4*20 carrier; potential side effects from certain drugs
(T;T) 5 CYP3A4*20 homozygote; side effects likely from many drugs
ReferenceGRCh38 38.1/141
Chromosome7
Position99758183
GeneCYP3A4
is asnp
is mentioned by
dbSNPrs67666821
ebirs67666821
HLIrs67666821
Exacrs67666821
Varsomers67666821
Maprs67666821
PheGenIrs67666821
hapmaprs67666821
1000 genomesrs67666821
hgdprs67666821
ensemblrs67666821
gopubmedrs67666821
geneviewrs67666821
scholarrs67666821
googlers67666821
pharmgkbrs67666821
gwascentralrs67666821
openSNPrs67666821
23andMers67666821
23andMe allrs67666821
SNP Nexus

SNPshotrs67666821
SNPdbers67666821
MSV3drs67666821
GWAS Ctlgrs67666821
Max Magnitude5
rs67666821 is a SNP describing the CYP3A4*20 allele.

The normal/common form for this SNP is actually the null (ie deleted) form; the very rare (< 0.06% frequency in Caucasians) form encoding a nonfunctional CYP3A4 protein has a T (in dbSNP orientation) at this location. As of 2006, it was the only CYP3A4 SNP with a known functional consequence.[PMID 16580902].

Carriers of one rs67666821(T) allele have an intermediate CYP3A4 metabolizer phenotype, and might be susceptible to side effects during drug therapy with substrates or inhibitors of CYP3A4 such as acetaminophen, codeine, cyclosporin A, diazepam and erythromycin.