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rs6795970

From SNPedia

Orientationplus
Stabilizedplus
Make rs6795970(A;A)
Make rs6795970(A;G)
Make rs6795970(G;G)
ReferenceGRCh38 38.1/141
Chromosome3
Position38725184
GeneSCN10A
is asnp
is mentioned by
dbSNPrs6795970
ebirs6795970
HLIrs6795970
Exacrs6795970
Varsomers6795970
Maprs6795970
PheGenIrs6795970
hapmaprs6795970
1000 genomesrs6795970
hgdprs6795970
ensemblrs6795970
gopubmedrs6795970
geneviewrs6795970
scholarrs6795970
googlers6795970
pharmgkbrs6795970
gwascentralrs6795970
openSNPrs6795970
23andMers6795970
23andMe allrs6795970
SNP Nexus

SNPshotrs6795970
SNPdbers6795970
MSV3drs6795970
GWAS Ctlgrs6795970
GMAF0.264
Max Magnitude
? (A;A) (A;G) (G;G) 28

[PMID 20062061] Genetic variation in SCN10A influences cardiac conduction

GWAS snp
PMID [PMID 20062063]
Trait Electrocardiographic traits
Title Several common variants modulate heart rate, PR interval and QRS duration
Risk Allele A
P-val 4E-9
Odds Ratio 5.17 [3.46-6.89] % SD increase


[PMID 21041692OA-icon.png] Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science


[PMID 20062060OA-icon.png] Genome-wide association study of PR interval.


[PMID 21347284OA-icon.png] Genome-wide association studies of the PR interval in African Americans.


GET Evidence
SCN10A-V1073A
aa_change Val1073Ala
aa_change_short V1073A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.70264
summary



GWAS snp
PMID [PMID 23463857OA-icon.png]
Trait Electrocardiographic conduction measures
Title Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.
Risk Allele A
P-val 5E-27
Odds Ratio .75 [NR] msec increase


[PMID 24072447OA-icon.png] Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation


[PMID 23092954OA-icon.png] SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.


[PMID 25085921] Common and Rare Variants in SCN10A Modulate the Risk of Atrial Fibrillation


[PMID 25691686] Common and Rare Variants in SCN10A Modulate the Risk of Atrial Fibrillation


[PMID 25691538] Role of common and rare variants in SCN10A: Results from the Brugada syndrome QRS locus gene discovery collaborative study


[PMID 26104176] Association Between Genetic Variation in the SCN10A Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy