Have questions? Visit https://www.reddit.com/r/SNPedia

rs6835457

From SNPedia

Orientationplus
Stabilizedplus
Make rs6835457(A;A)
Make rs6835457(A;G)
Make rs6835457(G;G)
ReferenceGRCh38 38.1/141
Chromosome4
Position122589971
is asnp
is mentioned by
dbSNPrs6835457
ebirs6835457
HLIrs6835457
Exacrs6835457
Varsomers6835457
Maprs6835457
PheGenIrs6835457
hapmaprs6835457
1000 genomesrs6835457
hgdprs6835457
ensemblrs6835457
gopubmedrs6835457
geneviewrs6835457
scholarrs6835457
googlers6835457
pharmgkbrs6835457
gwascentralrs6835457
openSNPrs6835457
23andMers6835457
23andMe allrs6835457
SNP Nexus

SNPshotrs6835457
SNPdbers6835457
MSV3drs6835457
GWAS Ctlgrs6835457
GMAF0.3719
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs6835457 is a SNP in the 3'-UTR flanking region of the IL21 gene.

A study including both European (4,248 patients) and African-Americans (1,569 patients) with lupus focusing on the IL2/IL21 gene region on chromosome 4q27 concluded that 2 tightly linked SNPs were associated with increased risk for the disease, rs907715 and rs6835457, with odds ratios of 1.16 (CI: 1.1-1.22, p=2x10e-8) and 1.11 (CI:1.05-1.17, p=9x10e-5), respectively.[PMID 21425124OA-icon.png]

[PMID 23172754OA-icon.png] Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility