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rs6855911

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 normal, but increased risk of gout
(A;G) 2 0.62x decreased risk for gout
(G;G) 2 rare, but 0.62x decreased risk for gout
ReferenceGRCh38 38.1/141
Chromosome4
Position9934286
GeneSLC2A9
is asnp
is mentioned by
dbSNPrs6855911
ebirs6855911
HLIrs6855911
Exacrs6855911
Varsomers6855911
Maprs6855911
PheGenIrs6855911
hapmaprs6855911
1000 genomesrs6855911
hgdprs6855911
ensemblrs6855911
gopubmedrs6855911
geneviewrs6855911
scholarrs6855911
googlers6855911
pharmgkbrs6855911
gwascentralrs6855911
openSNPrs6855911
23andMers6855911
23andMe allrs6855911
SNP Nexus

SNPshotrs6855911
SNPdbers6855911
MSV3drs6855911
GWAS Ctlgrs6855911
GMAF0.2567
Max Magnitude2
? (A;A) (A;G) (G;G) 28
[PMID 17997608OA-icon.png] risk for cardiovascular morbidity and mortality rs6855911 (p = 1.84E-16)

[PMID 18398472OA-icon.png] although no risk for coronary artery disease or myocardial infarction was observed, rs6855911 was associated with gout. The minor allele had a protective effect, with an allelic odds ratio of 0.62 (CI: 0.52-0.75, p = 3.2x10(-7)).

GWAS
SNP rs6855911
PubMedID [PMID 17997608OA-icon.png]
Condition Serum urate
Gene GLUT9
Risk Allele A
pValue 2.00E-016
OR 0.32
95% CI NR) mg/dl highe


[PMID 19890391OA-icon.png] Common polymorphisms influencing serum uric Acid levels contribute to susceptibility to gout, but not to coronary artery disease



[PMID 18487473OA-icon.png] Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI.


[PMID 18606621OA-icon.png] SLC2A9--a fructose transporter identified as a novel uric acid transporter.


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 19679263OA-icon.png] Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.


[PMID 20053405OA-icon.png] Sex and age interaction with genetic association of atherogenic uric acid concentrations.


[PMID 20972595] Association of an intronic SNP of SLC2A9 gene with serum uric acid levels in the Chinese male Han population by high-resolution melting method.


GET Evidence
rs6855911
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.328125
summary



[PMID 22723994OA-icon.png] Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach


[PMID 27511497] Association analysis of five SNP variants with gout in the Minnan population in China.