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rs6859

From SNPedia

Orientationplus
Stabilizedplus
Make rs6859(A;A)
Make rs6859(A;G)
Make rs6859(G;G)
ReferenceGRCh38 38.1/141
Chromosome19
Position44878777
GenePVRL2
is asnp
is mentioned by
dbSNPrs6859
ebirs6859
HLIrs6859
Exacrs6859
Varsomers6859
Maprs6859
PheGenIrs6859
hapmaprs6859
1000 genomesrs6859
hgdprs6859
ensemblrs6859
gopubmedrs6859
geneviewrs6859
scholarrs6859
googlers6859
pharmgkbrs6859
gwascentralrs6859
openSNPrs6859
23andMers6859
23andMe allrs6859
SNP Nexus

SNPshotrs6859
SNPdbers6859
MSV3drs6859
GWAS Ctlgrs6859
GMAF0.3898
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 18823527OA-icon.png]
Trait Alzheimer's disease
Title A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
Risk Allele A
P-val 5.9999999999999997E-14
Odds Ratio NR NR


The risk allele associated with late-onset Alzheimer's disease is A. [PMID 18823527OA-icon.png]

GWAS snp
PMID [PMID 20885792OA-icon.png]
Trait
Title Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities
Risk Allele A
P-val 1E-7
Odds Ratio 1.41 [1.24-1.60]
GWAS snp
PMID [PMID 22159054OA-icon.png]
Trait
Title A comprehensive genetic association study of Alzheimer disease in African Americans.
Risk Allele A
P-val 5E-7
Odds Ratio 1.5800 None


[PMID 19265542OA-icon.png] Performance of random forest when SNPs are in linkage disequilibrium.


[PMID 19734902OA-icon.png] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.


[PMID 21390209OA-icon.png] Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.


GET Evidence
rs6859
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.515873
summary



[PMID 23193196OA-icon.png] Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.


[PMID 26543236] Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population