Have questions? Visit https://www.reddit.com/r/SNPedia

rs6869366

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) >2x increased risk for bladder cancer
(G;T) 2x increased risk for bladder cancer
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome5
Position83075927
GeneTMEM167A, XRCC4
is asnp
is mentioned by
dbSNPrs6869366
ebirs6869366
HLIrs6869366
Exacrs6869366
Varsomers6869366
Maprs6869366
PheGenIrs6869366
hapmaprs6869366
1000 genomesrs6869366
hgdprs6869366
ensemblrs6869366
gopubmedrs6869366
geneviewrs6869366
scholarrs6869366
googlers6869366
pharmgkbrs6869366
gwascentralrs6869366
openSNPrs6869366
23andMers6869366
23andMe allrs6869366
SNP Nexus

SNPshotrs6869366
SNPdbers6869366
MSV3drs6869366
GWAS Ctlgrs6869366
GMAF0.09504
Max Magnitude0
? (G;G) (G;T) (T;T) 28
rs6869366, also known as G-1394T, is a SNP in the DNA repair XRCC4 gene.

A study of 158 Taiwanese patients found an association between carriers of a rs6869366(G) allele and increased risk for bladder cancer. The odds ratio was 2x for heterozygotes; no (T;T) homozygotes were seen in this study.[PMID 19443403]

Risk was further studied based on smoking history. Smokers who were also rs6869366(T) carriers were at even higher risk (crude OR=3.29, CI: 1.21-8.90, adjusted OR=3.35, CI=1.41-8.49), implying a gene-smoking interaction.[PMID 19443403]


[PMID 19729825] Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan

[PMID 20332465] Significant association of XRCC4 single nucleotide polymorphisms with childhood leukemia in Taiwan

[PMID 20683005] Colorectal Cancer and Genetic Polymorphism of DNA Double-strand Break Repair Gene XRCC4 in Taiwan


[PMID 21617942] Gene variants of XRCC4 and XRCC3 and their association with risk for urothelial bladder cancer


[PMID 21717429OA-icon.png] Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy

[PMID 17987338] A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan.


[PMID 18164646] A novel single nucleotide polymorphism in XRCC4 gene is associated with oral cancer susceptibility in Taiwanese patients.


[PMID 18630527] Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan.


[PMID 21506695] Do polymorphisms in XRCC4 influence prostate cancer susceptibility in North Indian population?


[PMID 23924833OA-icon.png] Association of XRCC3 and XRCC4 gene polymorphisms, family history of cancer and tobacco smoking with non-small-cell lung cancer in a Chinese population: a case-control study