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rs6910071

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G)
(G;G) 2 6x higher risk of rheumatoid arthritis
ReferenceGRCh38 38.1/141
Chromosome6
Position32315077
GeneC6orf10
is asnp
is mentioned by
dbSNPrs6910071
ebirs6910071
HLIrs6910071
Exacrs6910071
Varsomers6910071
Maprs6910071
PheGenIrs6910071
hapmaprs6910071
1000 genomesrs6910071
hgdprs6910071
ensemblrs6910071
gopubmedrs6910071
geneviewrs6910071
scholarrs6910071
googlers6910071
pharmgkbrs6910071
gwascentralrs6910071
openSNPrs6910071
23andMers6910071
23andMe allrs6910071
SNP Nexus

SNPshotrs6910071
SNPdbers6910071
MSV3drs6910071
GWAS Ctlgrs6910071
GMAF0.1309
Max Magnitude2
? (A;A) (A;G) (G;G) 28

This SNP, along with SNPs rs660895 and rs3817964, is a tag SNP for the HLA-DRB1*0401 allele.

The HLA-DRB1*0401 allele has been associated with higher risk for rheumatoid arthritis, and in particular, rheumatoid vasculitis. The association is seen particularly for individuals carrying two copies of, i.e. homozygous for, the allele. The reported odds ratio for rs6910071(G;G) homozygotes is 6.2 (CI: 1.01 - 37.9). [PMID 15529352]

The risk for rheumatoid arthritis may be higher for individuals carrying one copy (one "dose") of the HLA-DRB1*0401 allele, if they also carry a different HLA-DRB1 risk allele. In particular, *0401/*0404 individuals are reported to have an odds ratio for rheumatoid vasculitis of 4.1 (CI: 1.1 - 16.2), and *0401/*0101 individuals have an odds ratio of 4.0 (CI: 1.4 - 11.6). [PMID 15529352]

GWAS snp
PMID [PMID 20453842OA-icon.png]
Trait Rheumatoid arthritis
Title Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lock
Risk Allele G
P-val 0
Odds Ratio 2.88 [2.73-3.03]

[PMID 24270849OA-icon.png] rs6910071 was found to be associated with rheumatoid arthritis based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.

[PMID 15747258OA-icon.png] A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.

[PMID 20017995OA-icon.png] A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies.

[PMID 20018015OA-icon.png] Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis.

[PMID 20018025OA-icon.png] Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium.

[PMID 20018053OA-icon.png] A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests.

[PMID 20018067OA-icon.png] A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis.

[PMID 20018081OA-icon.png] Assessment of gene-covariate interactions by incorporating covariates into association mapping.

[PMID 21383967OA-icon.png] Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.


[PMID 23223422OA-icon.png] Identification of the NF-kappaB activating protein-like locus as a risk locus for rheumatoid arthritis.

GWAS snp
PMID [PMID 24449572OA-icon.png]
Trait Rheumatoid arthritis
Title Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
Risk Allele
P-val 2E-124
Odds Ratio 2.30 [2.14-2.46]