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rs6918698

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) normal risk
(C;G) ~normal risk
(G;G) 2.2x higher systemic sclerosis risk
ReferenceGRCh38 38.1/141
Chromosome6
Position131952117
GeneCTGF
is asnp
is mentioned by
dbSNPrs6918698
ebirs6918698
HLIrs6918698
Exacrs6918698
Varsomers6918698
Maprs6918698
PheGenIrs6918698
hapmaprs6918698
1000 genomesrs6918698
hgdprs6918698
ensemblrs6918698
gopubmedrs6918698
geneviewrs6918698
scholarrs6918698
googlers6918698
pharmgkbrs6918698
gwascentralrs6918698
openSNPrs6918698
23andMers6918698
23andMe allrs6918698
SNP Nexus

SNPshotrs6918698
SNPdbers6918698
MSV3drs6918698
GWAS Ctlgrs6918698
GMAF0.4986
Max Magnitude
? (C;C) (C;G) (G;G) 28
rs6918698, a common SNP located in the promoter of the CTGF gene, has been linked to increased risk for systemic sclerosis (scleroderma) based on a study of 500 Caucasian patients. The odds ratio is 2.2 for (G;G) homozygotes (p<0.001). The reason that the (C) allele appears to be protective is thought to be due to decreased CTGF activity.[PMID 17881752]
OMIM121009
DescCONNECTIVE TISSUE GROWTH FACTOR; CTGF
Variant
Relatedalso

[PMID 19243500] Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis


[PMID 22533709OA-icon.png] The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes


[PMID 19054818] Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population.


[PMID 19822645OA-icon.png] Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes.


[PMID 22503846] Connective tissue growth factor (CTGF/CCN2): A protagonist in cardiac allograft vasculopathy development?


[PMID 22554650OA-icon.png] Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil


[PMID 24121259] The Influence of CTGF Single-Nucleotide Polymorphisms on Outcomes in Crohn's Disease


[PMID 25030555] Association between Gene Polymorphisms of Connective Tissue Growth Factor and the Progression of Chronic Liver Disease Associated with Hepatitis C


[PMID 25502877OA-icon.png] Investigating the association between polymorphisms in connective tissue growth factor and susceptibility to colon carcinoma