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rs6922269

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 1.6x risk of coronary artery disease
(A;G) 1.2x risk of coronary artery disease
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome6
Position150931849
GeneMTHFD1L
is asnp
is mentioned by
dbSNPrs6922269
ebirs6922269
HLIrs6922269
Exacrs6922269
Varsomers6922269
Maprs6922269
PheGenIrs6922269
hapmaprs6922269
1000 genomesrs6922269
hgdprs6922269
ensemblrs6922269
gopubmedrs6922269
geneviewrs6922269
scholarrs6922269
googlers6922269
pharmgkbrs6922269
gwascentralrs6922269
openSNPrs6922269
23andMers6922269
23andMe allrs6922269
SNP Nexus

SNPshotrs6922269
SNPdbers6922269
MSV3drs6922269
GWAS Ctlgrs6922269
GMAF0.2906
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs6922269 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease.

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.17 (CI 1.04-1.32), and for homozygotes, 1.65 (CI 1.32-2.06). [PMID 17554300OA-icon.png]

GWAS
SNP rs6922269
PubMedID [PMID 17634449OA-icon.png]
Condition Coronary disease
Gene MTHFD1L
Risk Allele A
pValue 3.00E-008
OR 1.23
95% CI 1.15-1.33


[PMID 19164808OA-icon.png] Large scale association analysis of novel genetic loci for coronary artery disease


[PMID 18675980OA-icon.png] Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes



[PMID 19373437] Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population


[PMID 21463265OA-icon.png] Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population


[PMID 22216278OA-icon.png] Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease


[PMID 18780302OA-icon.png] Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 18979498OA-icon.png] The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.


[PMID 19135198] Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease.


[PMID 19198609OA-icon.png] Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.


[PMID 19336475OA-icon.png] Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.


[PMID 19750184OA-icon.png] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.


[PMID 19956433OA-icon.png] Genetics of coronary artery disease: focus on genome-wide association studies.


[PMID 20017983OA-icon.png] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.


[PMID 21804106OA-icon.png] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.


[PMID 22042884OA-icon.png] Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.


GET Evidence
rs6922269
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.285714
summary



[PMID 25809277] Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome