|(A;A)||2||1.6x risk of coronary artery disease|
|(A;G)||1.2x risk of coronary artery disease|
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.17 (CI 1.04-1.32), and for homozygotes, 1.65 (CI 1.32-2.06). [PMID 17554300]
[PMID 19164808] Large scale association analysis of novel genetic loci for coronary artery disease
[PMID 18675980] Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes
[PMID 19373437] Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population
[PMID 21463265] Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population
[PMID 22216278] Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease
[PMID 18780302] Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.
[PMID 18852197] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
[PMID 18979498] The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.
[PMID 19135198] Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease.
[PMID 19198609] Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
[PMID 19336475] Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
[PMID 19750184] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.
[PMID 20017983] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.
[PMID 21804106] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.
[PMID 22042884] Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 25809277] Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome