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rs6957

From SNPedia

Orientationminus
Stabilizedminus
Make rs6957(A;A)
Make rs6957(A;G)
Make rs6957(G;G)
ReferenceGRCh38 38.1/141
Chromosome19
Position41324701
GeneCCDC97
is asnp
is mentioned by
dbSNPrs6957
ebirs6957
HLIrs6957
Exacrs6957
Varsomers6957
Maprs6957
PheGenIrs6957
hapmaprs6957
1000 genomesrs6957
hgdprs6957
ensemblrs6957
gopubmedrs6957
geneviewrs6957
scholarrs6957
googlers6957
pharmgkbrs6957
gwascentralrs6957
openSNPrs6957
23andMers6957
23andMe allrs6957
SNP Nexus

SNPshotrs6957
SNPdbers6957
MSV3drs6957
GWAS Ctlgrs6957
GMAF0.2511
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 18281501] colorectal neoplasia

271 colorectal adenoma cases and 544 controls, and 535 colorectal adenocarcinoma cases and 656 controls.

  • rs6957(A) was associated with higher serum TGFbeta-1 [means (in ng/mL) and 95% confidence interval (95% CI) for AA or AG, 32.6 (30.6-34.7); GG, 29.0 (25.1-32.9); P(difference) = 0.05]
  • rs11466345(G;G) had a statistically significantly lower risk of adenocarcinoma [AG versus AA: odds ratio (OR), 0.9 (95% CI, 0.7-1.2); GG versus AA: OR, 0.4 (95% CI, 0.2-0.7); P(trend) = 0.01].
  • The haplotype carrying both variants was also statistically significantly associated with a reduced risk of adenocarcinoma (OR, 0.3; 95% CI, 0.1-0.8)


[PMID 19258388OA-icon.png] Genetic variation in the transforming growth factor-{beta}1 gene is associated with susceptibility to IgA nephropathy.


[PMID 15175276] The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).


[PMID 16780585OA-icon.png] Decorin and TGF-beta1 polymorphisms and development of COPD in a general population.


[PMID 18670143] The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese.


[PMID 19096005OA-icon.png] Variants in TGFB1, dust mite exposure, and disease severity in children with asthma.


[PMID 20479942OA-icon.png] Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.


[PMID 21320324OA-icon.png] The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study.


[PMID 21556788] Lack of association between the TGF-beta(1) gene and development of COPD in Asians: a case-control study and meta-analysis.


[PMID 23267696OA-icon.png] Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study