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rs6971

From SNPedia

Orientationminus
Stabilizedplus
Make rs6971(C;C)
Make rs6971(C;T)
Make rs6971(T;T)
ReferenceGRCh38 38.1/142
Chromosome22
Position43162920
GeneTSPO
is asnp
is mentioned by
dbSNPrs6971
ebirs6971
HLIrs6971
Exacrs6971
Varsomers6971
Maprs6971
PheGenIrs6971
hapmaprs6971
1000 genomesrs6971
hgdprs6971
ensemblrs6971
gopubmedrs6971
geneviewrs6971
scholarrs6971
googlers6971
pharmgkbrs6971
gwascentralrs6971
openSNPrs6971
23andMers6971
23andMe allrs6971
SNP Nexus

SNPshotrs6971
SNPdbers6971
MSV3drs6971
GWAS Ctlgrs6971
GMAF0.1823
Max Magnitude
? (C;C) (C;T) (T;T) 28
[PMID 22472607OA-icon.png] Translocator protein (18?kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA


[PMID 18389087OA-icon.png] Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing.


[PMID 22251896OA-icon.png] Identifying improved TSPO PET imaging probes through biomathematics: the impact of multiple TSPO binding sites in vivo.


[PMID 22895910] Whole Body Biodistribution and Radiation Dosimetry in Humans of a New PET Ligand, [(18)F]-FEPPA, to Image Translocator Protein (18 kDa)


GET Evidence
TSPO-T147A
aa_change Thr147Ala
aa_change_short T147A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency
summary



[PMID 23785173OA-icon.png] Influence of TSPO Genotype on 11C-PBR28 Standardized Uptake Values


[PMID 23942012OA-icon.png] Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18kDa Translocator Protein (TSPO)


[PMID 24071511] Quantification of the Specific Translocator Protein Signal of 18F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding


[PMID 22968319OA-icon.png] A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation.


[PMID 24904112] In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with 18F-PBR111 PET


[PMID 25707397] In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [(18)F]-FEPPA


[PMID 25833352] (11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas


[PMID 26472628] Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [(11)C]PBR28 PET Brain Imaging Study