| Geno
|
Mag
|
Summary
|
| (C;C)
|
1
|
No increased risk of osteoarthritis
|
| (C;T)
|
1
|
slight risk of osteoarthritis
|
| (T;T)
|
1
|
risk of osteoarthritis
|
[PMID 22763110
] Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association studyResearch reported in the Lancet: "identified five genome-wide significant loci (binomial test p≤5·0×10−8) for association with osteoarthritis and three loci just below this threshold. The strongest association was on chromosome 3 with rs6976 (odds ratio 1·12 [95% CI 1·08—1·16]; p=7·24×10−11), which is in perfect linkage disequilibrium with rs11177. This SNP encodes a missense polymorphism within the nucleostemin-encoding gene GNL3. Levels of nucleostemin were raised in chondrocytes from patients with osteoarthritis in functional studies."
] Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association studyResearch reported in the Lancet: "identified five genome-wide significant loci (binomial test p≤5·0×10−8) for association with osteoarthritis and three loci just below this threshold. The strongest association was on chromosome 3 with rs6976 (odds ratio 1·12 [95% CI 1·08—1·16]; p=7·24×10−11), which is in perfect linkage disequilibrium with rs11177. This SNP encodes a missense polymorphism within the nucleostemin-encoding gene GNL3. Levels of nucleostemin were raised in chondrocytes from patients with osteoarthritis in functional studies."
