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rs6976

From SNPedia

Orientationplus
Stabilizedplus
Make rs6976(C;C)
Make rs6976(C;T)
Make rs6976(T;T)
ReferenceGRCh38 38.1/141
Chromosome3
Position52694788
GeneGLT8D1, GNL3
is asnp
is mentioned by
dbSNPrs6976
ebirs6976
HLIrs6976
Exacrs6976
Varsomers6976
Maprs6976
PheGenIrs6976
hapmaprs6976
1000 genomesrs6976
hgdprs6976
ensemblrs6976
gopubmedrs6976
geneviewrs6976
scholarrs6976
googlers6976
pharmgkbrs6976
gwascentralrs6976
openSNPrs6976
23andMers6976
23andMe allrs6976
SNP Nexus

SNPshotrs6976
SNPdbers6976
MSV3drs6976
GWAS Ctlgrs6976
GMAF0.3834
Max Magnitude
? (C;C) (C;T) (T;T) 28
Research reported in the Lancet: "identified five genome-wide significant loci (binomial test p≤5·0×10−8) for association with osteoarthritis and three loci just below this threshold. The strongest association was on chromosome 3 with rs6976 (odds ratio 1·12 [95% CI 1·08—1·16]; p=7·24×10−11), which is in perfect linkage disequilibrium with rs11177. This SNP encodes a missense polymorphism within the nucleostemin-encoding gene GNL3. Levels of nucleostemin were raised in chondrocytes from patients with osteoarthritis in functional studies."

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study [1]

[PMID 22763110OA-icon.png] Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study