|?|| (C;C) (C;T) (T;T) ||28|
Research reported in the Lancet: "identified five genome-wide significant loci (binomial test p≤5·0×10−8) for association with osteoarthritis and three loci just below this threshold. The strongest association was on chromosome 3 with rs6976 (odds ratio 1·12 [95% CI 1·08—1·16]; p=7·24×10−11), which is in perfect linkage disequilibrium with rs11177
. This SNP encodes a missense polymorphism within the nucleostemin-encoding gene GNL3. Levels of nucleostemin were raised in chondrocytes from patients with osteoarthritis in functional studies."
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study
[PMID 22763110] Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study