Have questions? Visit https://www.reddit.com/r/SNPedia

rs7014346

From SNPedia

Orientationplus
Stabilizedplus
Make rs7014346(A;A)
Make rs7014346(A;G)
Make rs7014346(G;G)
ReferenceGRCh38 38.1/141
Chromosome8
Position127412547
GeneLOC101930033
is asnp
is mentioned by
dbSNPrs7014346
ebirs7014346
HLIrs7014346
Exacrs7014346
Varsomers7014346
Maprs7014346
PheGenIrs7014346
hapmaprs7014346
1000 genomesrs7014346
hgdprs7014346
ensemblrs7014346
gopubmedrs7014346
geneviewrs7014346
scholarrs7014346
googlers7014346
pharmgkbrs7014346
gwascentralrs7014346
openSNPrs7014346
23andMers7014346
23andMe allrs7014346
SNP Nexus

SNPshotrs7014346
SNPdbers7014346
MSV3drs7014346
GWAS Ctlgrs7014346
GMAF0.326
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 18839428] colorectal cancer rs10505477 and rs6983267 yielded allelic p-values of 1.42 x 10(-7) and 2.57 x 10(-7), respectively with OR=1.50 (95% CI: 1.29-1.75). Risk region was delineated by SNPs rs10505477 and rs7014346 and comprised 17 kb
GWAS
SNP rs7014346
PubMedID [PMID 18372901OA-icon.png]
Condition Colorectal cancer
Gene POU5FIP1, HsG57825, DQ515897
Risk Allele A
pValue 9.00E-026
OR 1.19
95% CI 1.15-1.23


OMIM611469
DescCOLORECTAL CANCER, SUSCEPTIBILITY TO, 2; CRCS2
Variant
Relatedalso
[PMID 20659471OA-icon.png] Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent

[PMID 21097774] Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome


[PMID 19011631OA-icon.png] Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.


[PMID 19857256OA-icon.png] Association between an 8q24 locus and the risk of colorectal cancer in Japanese.


GET Evidence
rs7014346
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.726562
summary



[PMID 23359760OA-icon.png] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population


[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.


[PMID 26579801OA-icon.png] Correlation Between CASC8, SMAD7 Polymorphisms and the Susceptibility to Colorectal Cancer: An Updated Meta-Analysis Based on GWAS Results


[PMID 26885031] Association of 8q23-24 region (8q23.3 loci and 8q24.21 loci) with susceptibility to colorectal cancer: a systematic and updated meta-analysis.


[PMID 27689194] Single Nucleotide Polymorphisms within the 8Q24 Region are Not Associated with the Risk of Intraductal Papillary Mucinous Neoplasms of the Pancreas.


[PMID 27769063] Risk of eighteen genome-wide association study-identified genetic variants for colorectal cancer and colorectal adenoma in Han Chinese.