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rs7017300

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal risk
(A;C) 1.7x increased risk for prostate cancer
(C;C) 1.7x increased risk for prostate cancer
ReferenceGRCh38 38.1/141
Chromosome8
Position127513023
is asnp
is mentioned by
dbSNPrs7017300
ebirs7017300
HLIrs7017300
Exacrs7017300
Varsomers7017300
Maprs7017300
PheGenIrs7017300
hapmaprs7017300
1000 genomesrs7017300
hgdprs7017300
ensemblrs7017300
gopubmedrs7017300
geneviewrs7017300
scholarrs7017300
googlers7017300
pharmgkbrs7017300
gwascentralrs7017300
openSNPrs7017300
23andMers7017300
23andMe allrs7017300
SNP Nexus

SNPshotrs7017300
SNPdbers7017300
MSV3drs7017300
GWAS Ctlgrs7017300
GMAF0.2185
Max Magnitude0
? (A;A) (A;C) (C;C) 28
rs7017300 is one of 4 tightly linked SNPs in the "locus 1" region of 8q24 chromosomal region, which has been linked in several studies to prostate cancer, initially through rs1447295.[PMID 17925536]

In a study of 1,563 patients of European ancestry, the odds ratio for prostate cancer associated with risk genotypes of locus 1 were reported as 1.70 (CI: 1.39-2.07). Two other regions of chromosome 8q24 were also studied.[PMID 17925536]


[PMID 21086507] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP)


[PMID 18670647OA-icon.png] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.


[PMID 18704501OA-icon.png] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.


[PMID 21456070OA-icon.png] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP).


[PMID 23532531] Common Variants at 8q24 are Associated with Prostate Cancer Risk in Serbian Population