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rs7025486

From SNPedia

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Geno Mag Summary
(A;A) 1.6 slight (1.4x) increase in risk for abdominal aortic aneurysm and other vascular disorders
(A;G) 1.4 slight (1.2x) increase in risk for abdominal aortic aneurysm and some vascular disorders
(G;G) 0 common/normal
ReferenceGRCh38 38.1/141
Chromosome9
Position121660124
GeneDAB2IP
is asnp
is mentioned by
dbSNPrs7025486
ebirs7025486
HLIrs7025486
Exacrs7025486
Varsomers7025486
Maprs7025486
PheGenIrs7025486
hapmaprs7025486
1000 genomesrs7025486
hgdprs7025486
ensemblrs7025486
gopubmedrs7025486
geneviewrs7025486
scholarrs7025486
googlers7025486
pharmgkbrs7025486
gwascentralrs7025486
openSNPrs7025486
23andMers7025486
23andMe allrs7025486
SNP Nexus

SNPshotrs7025486
SNPdbers7025486
MSV3drs7025486
GWAS Ctlgrs7025486
GMAF0.2603
Max Magnitude1.6
? (A;A) (A;G) (G;G) 28
rs7025486(A) was associated with up to a 20% increased risk of the various vascular diseases, with an odds ratio of 1.21 for abdominal aortic aneurysm (AAA) (p = 4.6x10-10), 1.18 for early onset myocardial infarction (MI) (p = 3.1x10-5), 1.14 for peripheral arterial disease PAD (p = 3.9x10-5), and 1.2 for pulmonary embolism (PE) (p = 00030), but it was not associated with intracranial aneurysm or ischemic stroke. [PMID 20622881OA-icon.png] An individual who carried two copies of this allele would have around a 44% increased risk of AAA.

No association was seen between the A allele and common risk factors for arterial and venous disease—smoking, lipid levels, obesity, type 2 diabetes, and hypertension. theheart.org

DeCode reports that the rs7025486(A;A) genotype is associated with 1.21x odds of peripheral arterial disease (PAD) [PMID 18385739OA-icon.png] and 1.32x odds of abdominal aortic aneurysm (AAA) [PMID 20622881OA-icon.png].

GWAS snp
PMID [PMID 20622881OA-icon.png]
Trait Abdominal aortic aneurysm
Title Genome-wide association study identifies a sequence variant with the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
Risk Allele A
P-val 5E-10
Odds Ratio 1.21 [1.14-1.28]


[PMID 21444365OA-icon.png] Association of a sequence variant in DAB2IP with coronary heart disease