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rs705379

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) lowest arylesterase activity
(A;G) intermediate arylesterase activity
(G;G) highest arylesterase activity
ReferenceGRCh38 38.1/141
Chromosome7
Position95324583
GenePON1
is asnp
is mentioned by
dbSNPrs705379
ebirs705379
HLIrs705379
Exacrs705379
Varsomers705379
Maprs705379
PheGenIrs705379
hapmaprs705379
1000 genomesrs705379
hgdprs705379
ensemblrs705379
gopubmedrs705379
geneviewrs705379
scholarrs705379
googlers705379
pharmgkbrs705379
gwascentralrs705379
openSNPrs705379
23andMers705379
23andMe allrs705379
SNP Nexus

SNPshotrs705379
SNPdbers705379
MSV3drs705379
GWAS Ctlgrs705379
GMAF0.3815
Max Magnitude
rs705379, also known as -108C/T or -107C/T, is a SNP in the PON1 paraoxonase 1 gene.

[PMID 11335891OA-icon.png] Variation in the amount of PON1 activity has been reported to primarily involve this SNP, with the following average values of aryesterase activity reported per genotype (sample no. in parentheses):

GG (94) 125.8 ± 45.6
AG (188) 102.9 ± 37.6
AA (94) 68.6 ± 27.9


[PMID 20488557] Decreased serum arylesterase activity in autism spectrum disorders


[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.


[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.


[PMID 19321847OA-icon.png] A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.


[PMID 19401444OA-icon.png] Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism.


[PMID 20056567OA-icon.png] Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.


[PMID 21223581OA-icon.png] Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.


[PMID 21543280OA-icon.png] Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.


[PMID 22388798OA-icon.png] Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.


[PMID 23167629] Common genetic variants in the myeloperoxidase and paraoxonase genes and the related cancer risk: a review


[PMID 24448003] Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults


[PMID 22854640OA-icon.png] Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure.


[PMID 22956172OA-icon.png] Regulatory regions of the paraoxonase 1 (PON1) gene are associated with neovascular age-related macular degeneration (AMD).


ClinVar
Risk rs705379(A;A)
Alt rs705379(A;A)
Reference rs705379(G;G)
Significance Other
Disease Enzyme activity finding
Variation info
Gene PON1
CLNDBN Enzyme activity finding
Reversed 0
HGVS NC_000007.13:g.94953895G>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000133466.2,