|(C;C)||2.1||Small reduction in coronary heart disease risk from alcohol consumption|
|(C;T)||2.1||Small reduction in heart disease risk from drinking alcohol|
|(T;T)||2.2||B2B2 genotype; some reduction in heart disease risk from moderate alcohol consumption|
However, high HDL cholesterol, at least when combined with another HDL raising SNP (rs1800588), doesn't appear to actually protect individuals from coronary artery disease, at least based on one study of ~800 Caucasian male patients. [PMID 18164013]
A similarly confusing picture emerges from a study of two populations of 10,000+ individuals each. The distribution of the CETP genotype was observed to be different in population-based studies compared with studies in populations selected by high cardiovascular risk, and contradictory results were seen when trying to figure out if the TaqIB SNP predicted whether drugs would lower plasma lipids or cardiovascular outcome.[PMID 18518852]
A meta-analysis concluded that there probably was a statistically significant, but weak, association for this SNP. For each rs708272(T) allele inherited, individuals had lower mean CETP mass (-9.7%; CI: -11.7% to -7.8%), lower mean CETP activity (-8.6%; CI: -13.0% to -4.1%), higher mean high-density lipoprotein cholesterol (HDL-C) concentrations (4.5%; CI: 3.8%-5.2%), and higher mean apolipoprotein A-I concentrations (2.4%; CI, 1.6%-3.2%). The combined per-allele odds ratios (ORs) for coronary disease were 0.95 (CI: 0.92-0.99).[PMID 18560005]
A prospective cohort study of 18,245 initially healthy American women over a 10-year period found similar results with respect to HDL-C levels and (inversely) risk of myocardial infarction; rs708272(T) was associated with a per-allele increase in HDL-C levels of 3.1 mg/dL and a concordant 24 percent lower risk of future myocardial infarction (age-adjusted HR 0.76, CI: 0.62-0.94).[PMID 20031564]
rs708272 has also been associated with reduced coronary heart disease risk in those drinking alcohol. More specifically, a 2014 study by Mehlig et al., ([PMID 25288221] studying 618 patients with CHD found that the B2B2 genotype, rs708272(T;T)), had a reduced risk (odds ratio 0.21) for CHD in intermediate vs low drinkers.[PMID 20031564] Polymorphism in the CETP Gene Region, HDL Cholesterol, and Risk of Future Myocardial Infarction: Genomewide Analysis Among 18 245 Initially Healthy Women From the Women's Genome Health Study
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