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rs7089424

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 2.5 moderately (~4x) increased risk for acute lymphoblastic leukemia
(G;T) 1.5 somewhat (~2x) increased risk for acute lymphoblastic leukemia
(T;T) 0 common/normal
ReferenceGRCh38 38.1/142
Chromosome10
Position61992400
GeneARID5B
is asnp
is mentioned by
dbSNPrs7089424
ebirs7089424
HLIrs7089424
Exacrs7089424
Varsomers7089424
Maprs7089424
PheGenIrs7089424
hapmaprs7089424
1000 genomesrs7089424
hgdprs7089424
ensemblrs7089424
gopubmedrs7089424
geneviewrs7089424
scholarrs7089424
googlers7089424
pharmgkbrs7089424
gwascentralrs7089424
openSNPrs7089424
23andMers7089424
23andMe allrs7089424
SNP Nexus

SNPshotrs7089424
SNPdbers7089424
MSV3drs7089424
GWAS Ctlgrs7089424
GMAF0.3287
Max Magnitude2.5
? (G;G) (G;T) (T;T) 28
GWAS snp
PMID [PMID 19684604]
Trait Acute lymphoblastic leukemia (childhood)
Title Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
Risk Allele C
P-val 7E-19
Odds Ratio 1.65 [1.54-1.76]
OMIM613065
Desc
Variant
Relatedalso
[PMID 20460642OA-icon.png] Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia.

[PMID 20919861] Variation at 7p12.2 and 10q21.2 influences childhood acute lymphoblastic leukemia risk in the Thai population and may contribute to racial differences in leukemia incidence.


GET Evidence
rs7089424
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.328125
summary



[PMID 25124600] Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis


[PMID 25761407] Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children


[PMID 24707947] Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk


[PMID 26575185OA-icon.png] Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA