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rs7101429

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) higher Alzheimer's risk if ApoE4 also present
(A;G) 1.8 0.70x reduced risk for Alzheimer's risk
(G;G) 2 0.70x reduced risk for Alzheimer's risk
ReferenceGRCh38 38.1/141
Chromosome11
Position78281921
GeneGAB2
is asnp
is mentioned by
dbSNPrs7101429
ebirs7101429
HLIrs7101429
Exacrs7101429
Varsomers7101429
Maprs7101429
PheGenIrs7101429
hapmaprs7101429
1000 genomesrs7101429
hgdprs7101429
ensemblrs7101429
gopubmedrs7101429
geneviewrs7101429
scholarrs7101429
googlers7101429
pharmgkbrs7101429
gwascentralrs7101429
openSNPrs7101429
23andMers7101429
23andMe allrs7101429
SNP Nexus

SNPshotrs7101429
SNPdbers7101429
MSV3drs7101429
GWAS Ctlgrs7101429
GMAF0.2254
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs7101429 is a SNP in the GRB2-associated binding protein 2 GAB2 gene.

In a study of 4000 DNA samples from ~1300 families affected by Alzheimer's disease, there was a reduced risk (0.70x; p = .002) among carriers of the rs7101429(G) minor allele.[PMID 19204162]


[PMID 19204163OA-icon.png] GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results.


[PMID 21285854] Association Study of the GAB2 Gene With the Risk of Alzheimer Disease in the Chinese Population


[PMID 17553421OA-icon.png] GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.


[PMID 22856364OA-icon.png] Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins


[PMID 23071633OA-icon.png] Mining pure, strict epistatic interactions from high-dimensional datasets: ameliorating the curse of dimensionality.