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rs710446

From SNPedia

Orientationminus
Stabilizedminus
Make rs710446(A;A)
Make rs710446(A;G)
Make rs710446(G;G)
ReferenceGRCh38 38.1/141
Chromosome3
Position186742138
GeneKNG1
is asnp
is mentioned by
dbSNPrs710446
ebirs710446
HLIrs710446
Exacrs710446
Varsomers710446
Maprs710446
PheGenIrs710446
hapmaprs710446
1000 genomesrs710446
hgdprs710446
ensemblrs710446
gopubmedrs710446
geneviewrs710446
scholarrs710446
googlers710446
pharmgkbrs710446
gwascentralrs710446
openSNPrs710446
23andMers710446
23andMe allrs710446
SNP Nexus

SNPshotrs710446
SNPdbers710446
MSV3drs710446
GWAS Ctlgrs710446
GMAF0.4192
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 20303064OA-icon.png]
Trait Activated partial thromboplastin time
Title Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time
Risk Allele G
P-val 1E-21
Odds Ratio 0.36 [0.29-0.43] unit decrease


[PMID 21270443] KNG1 Ile581Thr and susceptibility to venous thrombosis.

GWAS snp
PMID [PMID 22703881OA-icon.png]
Trait
Title Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease.
Risk Allele C
P-val 0
Odds Ratio 1.1800 None


GET Evidence
KNG1-I581T
aa_change Ile581Thr
aa_change_short I581T
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.46875
summary



[PMID 22701019] A genome-wide association study identifies KNG1 as a genetic determinant of plasma factor XI Level and activated partial thromboplastin time.


[PMID 25779970] Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans


[PMID 26159646] Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect and Epistatic Interactions in a Chinese Population