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rs7192

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common/normal
(G;T) 1.7 1.7x increased risk for developing a peanut allergy
(T;T) 3 3x higher risk for developing a peanut allergy
ReferenceGRCh38 38.1/141
Chromosome6
Position32443869
GeneHLA-DRA
is asnp
is mentioned by
dbSNPrs7192
ebirs7192
HLIrs7192
Exacrs7192
Varsomers7192
Maprs7192
PheGenIrs7192
hapmaprs7192
1000 genomesrs7192
hgdprs7192
ensemblrs7192
gopubmedrs7192
geneviewrs7192
scholarrs7192
googlers7192
pharmgkbrs7192
gwascentralrs7192
openSNPrs7192
23andMers7192
23andMe allrs7192
SNP Nexus

SNPshotrs7192
SNPdbers7192
MSV3drs7192
GWAS Ctlgrs7192
GMAF0.3678
Max Magnitude3

rs7192, also known as Leu242Val or L242V, is a SNP in the HLA-DRA gene on chromosome 6.

A study of several thousand children and their parents, most with food allergies, concluded that two SNPs, rs7192 and rs9275596, are associated with increased susceptibility to developing a peanut allergy in populations of European ancestry. The odds ratio reported for rs7192(T) were 1.7 (p=10e-8).[PMID 25710614OA-icon.png]

? (G;G) (G;T) (T;T) 28
Detecting significant single-nucleotide polymorphisms in a rheumatoid arthritis study using random forests[PMID 20018063OA-icon.png]


[PMID 20587610] Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection

OMIM142395
Desc
Variant
Relatedalso
GWAS snp
PMID [PMID 22541561OA-icon.png]
Trait
Title A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.
Risk Allele T
P-val 0.000003
Odds Ratio 1.2900 None


[PMID 18204098] Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.


[PMID 19143810OA-icon.png] Haplotype-based search for SNPs associated with differential type 1 diabetes risk among chromosomes carrying a specific HLA DRB1-DQA1-DQB1 haplotype.


[PMID 20018067OA-icon.png] A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis.


[PMID 20018081OA-icon.png] Assessment of gene-covariate interactions by incorporating covariates into association mapping.


[PMID 22201026] Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet's disease.


GET Evidence
HLA-DRA-L242V
aa_change Leu242Val
aa_change_short L242V
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.600611
summary



[PMID 23200760] Pathway analysis of genome-wide association study on asthma


[PMID 23053960] Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.


[PMID 23238918] Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis.