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rs7208505

From SNPedia

Orientationplus
Stabilizedplus
Make rs7208505(A;A)
Make rs7208505(A;G)
Make rs7208505(G;G)
ReferenceGRCh38 38.1/141
Chromosome17
Position59110368
GeneSKA2
is asnp
is mentioned by
dbSNPrs7208505
ebirs7208505
HLIrs7208505
Exacrs7208505
Varsomers7208505
Maprs7208505
PheGenIrs7208505
hapmaprs7208505
1000 genomesrs7208505
hgdprs7208505
ensemblrs7208505
gopubmedrs7208505
geneviewrs7208505
scholarrs7208505
googlers7208505
pharmgkbrs7208505
gwascentralrs7208505
openSNPrs7208505
23andMers7208505
23andMe allrs7208505
SNP Nexus

SNPshotrs7208505
SNPdbers7208505
MSV3drs7208505
GWAS Ctlgrs7208505
Max Magnitude
? (A;A) (A;G) (G;G) 28
Located in the 3' UTR of the SKA2 gene, rs7208505 is reported in a small study to be partially associated with tendencies towards suicide. In most ethnic groups, the more common allele - in dbSNP orientation - is rs7208505(A), and the less common is rs7208505(G). This latter, less common allele leads to the existence (on both strands) of a CpG dinucleotide capable of being methylated (and thereby lowering SKA2 and microRNA-301a expression).


In what is termed an additive genetic and epigenetic association, postmortem analysis of a relatively small number of brains indicates that while carrying the rs7208505(G) allele is not on it's own linked to higher suicide risk, harboring the methylated dinucleotide containing this allele may be, especially in the presence of higher waking levels of a marker for increased risk, cortisol.[PMID 25073599OA-icon.png]

The authors also distinguish between at least three categories of suicide risk: suicide ideation (thinking about it), suicide attempts, and last, death from suicide. The study sample number was too low to sort out all the variables in relation to these categories.


[PMID 26324104OA-icon.png] SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans