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rs72547513(A;A)

From SNPedia

Is agenotype
ofrs72547513
GeneCYP1A2
Chromosome15
Position74,750,296
mentionedby
Geno Mag Summary
(A;A)
(A;C) 2
(C;C)

also known as F186L, Phe186Leu, c.558C>A, g.32755C>A, g.45833194C>A

According to the literature, this is the cause of the CYP1A2*11 homozygote which produces 5% Vmax of the normal enzyme level. However 23andMe data shows that A is more common.

[PMID 14563787] in allele CYP1A2*11; drastic reduction in O-deethylation of phenacetin and 7-ethoxyresorufin; has a Vmax of approximately 5% of that of the wild-type and 5-fold lower Km value.