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rs725613

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis risk
(A;C) 1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis risk
(C;C) normal
ReferenceGRCh38 38.1/141
Chromosome16
Position11075826
GeneCLEC16A
is asnp
is mentioned by
dbSNPrs725613
ebirs725613
HLIrs725613
Exacrs725613
Varsomers725613
Maprs725613
PheGenIrs725613
hapmaprs725613
1000 genomesrs725613
hgdprs725613
ensemblrs725613
gopubmedrs725613
geneviewrs725613
scholarrs725613
googlers725613
pharmgkbrs725613
gwascentralrs725613
openSNPrs725613
23andMers725613
23andMe allrs725613
SNP Nexus

SNPshotrs725613
SNPdbers725613
MSV3drs725613
GWAS Ctlgrs725613
GMAF0.3714
Max Magnitude
? (A;A) (A;C) (C;C) 28
[PMID 17632545] associated with type-1 diabetes

In a separate study, Sardinians with either type-1 diabetes (1,037 patients) or multiple sclerosis (1,498 patients) plus matched controls were genotyped for rs725613. In this study, the rs725613(A) allele was positively associated not only with type-1 diabetes (odds ratio 1.15, p = 5.1 x 10e-3) but also with multiple sclerosis (odds ratio = 1.21, p = 6.7 x 10e-5).[PMID 18946483]

[PMID 19178520] rs725613 was strongly associated with T1D in the Han Chinese population (P = 0.00007, odds ratio (OR) = 0.527, 95% confidence interval (CI) = 0.383-0.726)

OMIM222100
DescDIABETES MELLITUS, INSULIN-DEPENDENT; IDDM
Variant
Relatedalso
OMIM611303
DescC-TYPE LECTIN DOMAIN FAMILY 16, MEMBER A; CLEC16A
Variant
Relatedalso


[PMID 20849399] More CLEC16A gene variants associated with multiple sclerosis

[PMID 18840781OA-icon.png] Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.

[PMID 20405052OA-icon.png] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.


[PMID 23922971OA-icon.png] Genetic associations with diabetes: meta-analyses of 10 candidate polymorphisms