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rs72646508

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common
(C;T) 3 Lowered LDL-C and reduced risk for coronary events
(T;T) 3 Lower LDL-C and lowered risk for coronary events
ReferenceGRCh38 38.1/141
Chromosome1
Position55052749
GenePCSK9
is asnp
is mentioned by
dbSNPrs72646508
ebirs72646508
HLIrs72646508
Exacrs72646508
Varsomers72646508
Maprs72646508
PheGenIrs72646508
hapmaprs72646508
1000 genomesrs72646508
hgdprs72646508
ensemblrs72646508
gopubmedrs72646508
geneviewrs72646508
scholarrs72646508
googlers72646508
pharmgkbrs72646508
gwascentralrs72646508
openSNPrs72646508
23andMers72646508
23andMe allrs72646508
SNP Nexus

SNPshotrs72646508
SNPdbers72646508
MSV3drs72646508
GWAS Ctlgrs72646508
Max Magnitude3
rs72646508, also known as L253F, is a SNP in the PCSK9 gene.

It has been reported in several studies (including [PMID 16554528] and [PMID 18354102]) to be associated with reductions in total cholesterol as well as LDL-C, and most importantly, with significantly lowered risk for coronary events.