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rs727153

From SNPedia

Orientationminus
Stabilizedminus
Make rs727153(A;A)
Make rs727153(A;G)
Make rs727153(G;G)
ReferenceGRCh38 38.1/141
Chromosome4
Position154733269
GeneLRAT
is asnp
is mentioned by
dbSNPrs727153
ebirs727153
HLIrs727153
Exacrs727153
Varsomers727153
Maprs727153
PheGenIrs727153
hapmaprs727153
1000 genomesrs727153
hgdprs727153
ensemblrs727153
gopubmedrs727153
geneviewrs727153
scholarrs727153
googlers727153
pharmgkbrs727153
gwascentralrs727153
openSNPrs727153
23andMers727153
23andMe allrs727153
SNP Nexus

SNPshotrs727153
SNPdbers727153
MSV3drs727153
GWAS Ctlgrs727153
GMAF0.326
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 18823527OA-icon.png]
Trait Alzheimer's disease
Title A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
Risk Allele C
P-val 0.0000030000000000000001
Odds Ratio 1.63 [1.37-1.95]


This SNP is near the gene for lecithin retinol acyltransferase (phosphatidylcholine-retinol O-acetyltransferase) or LRAT, which is involved in Vitamin A metabolism; the risk allele is reportedly G (in dbSNP orientation). [PMID 18823527OA-icon.png]



[PMID 20574532OA-icon.png] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.


GET Evidence
rs727153
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.695312
summary Associated with LOAD (late Onset Alzheimer's disease) .