|?|| (A;A) (A;G) (G;G) ||28|
is a SNP in the sex-hormone binding globulin SHBG
gene. SHBG binds steroid hormones, mostly testosterone and estradiol, rendering them biologically unavailable.
[PMID 21252242] Based on a study of 758 women in 430 families, rs727428 is associated with levels of that sex-hormone binding globulin hormone, independent of the effects of insulin resistance and obesity. Specifically, levels of SHBG were decreased approximately 13% in (A;G) heterozygotes and 27% in (A;A) homozygotes compared with (G;G) homozygotes. [Note: designation of alleles is as shown in dbSNP.]
[PMID 19064566] Haplotype analysis suggested that rs858518, rs727428, or a variant in linkage disequilibrium with them acts to decrease SHBG levels but that this effect is neutralized by rs6259.
This SNP was previously associated with risk of type 2 diabetes mellitus.
[PMID 22675492] Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women
[PMID 12466288] Haplotype and linkage disequilibrium architecture for human cancer-associated genes.
[PMID 17411440] Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study.
|| [PMID 22936694]
|| Androgen levels
|| Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men.
| Risk Allele
| Odds Ratio
|| .07 [0.053-0.093] unit decrease
[PMID 23001781] Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women.
[PMID 26602056] The rs5934505 single nucleotide polymorphism (SNP) is associated with low testosterone and late-onset hypogonadism, but the rs10822184 SNP is associated with overweight and obesity in a Chinese Han population: a case-control study