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rs727428

From SNPedia

Orientationminus
Stabilizedminus
Make rs727428(A;A)
Make rs727428(A;G)
Make rs727428(G;G)
ReferenceGRCh38 38.1/141
Chromosome17
Position7634474
GeneSHBG
is asnp
is mentioned by
dbSNPrs727428
ebirs727428
HLIrs727428
Exacrs727428
Varsomers727428
Maprs727428
PheGenIrs727428
hapmaprs727428
1000 genomesrs727428
hgdprs727428
ensemblrs727428
gopubmedrs727428
geneviewrs727428
scholarrs727428
googlers727428
pharmgkbrs727428
gwascentralrs727428
openSNPrs727428
23andMers727428
23andMe allrs727428
SNP Nexus

SNPshotrs727428
SNPdbers727428
MSV3drs727428
GWAS Ctlgrs727428
GMAF0.4646
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs727428 is a SNP in the sex-hormone binding globulin SHBG gene. SHBG binds steroid hormones, mostly testosterone and estradiol, rendering them biologically unavailable.

[PMID 21252242OA-icon.png] Based on a study of 758 women in 430 families, rs727428 is associated with levels of that sex-hormone binding globulin hormone, independent of the effects of insulin resistance and obesity. Specifically, levels of SHBG were decreased approximately 13% in (A;G) heterozygotes and 27% in (A;A) homozygotes compared with (G;G) homozygotes. [Note: designation of alleles is as shown in dbSNP.]

[PMID 19064566OA-icon.png] Haplotype analysis suggested that rs858518, rs727428, or a variant in linkage disequilibrium with them acts to decrease SHBG levels but that this effect is neutralized by rs6259.

This SNP was previously associated with risk of type 2 diabetes mellitus.


[PMID 22675492OA-icon.png] Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women


[PMID 12466288OA-icon.png] Haplotype and linkage disequilibrium architecture for human cancer-associated genes.


[PMID 17411440OA-icon.png] Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study.

GWAS snp
PMID [PMID 22936694OA-icon.png]
Trait Androgen levels
Title Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men.
Risk Allele T
P-val 1E-12
Odds Ratio .07 [0.053-0.093] unit decrease


[PMID 23001781] Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women.


[PMID 26602056] The rs5934505 single nucleotide polymorphism (SNP) is associated with low testosterone and late-onset hypogonadism, but the rs10822184 SNP is associated with overweight and obesity in a Chinese Han population: a case-control study