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rs727479

From SNPedia

Orientationminus
Stabilizedminus
Make rs727479(G;G)
Make rs727479(G;T)
Make rs727479(T;T)
ReferenceGRCh38 38.1/141
Chromosome15
Position51242350
GeneCYP19A1, MIR4713
is asnp
is mentioned by
dbSNPrs727479
ebirs727479
HLIrs727479
Exacrs727479
Varsomers727479
Maprs727479
PheGenIrs727479
hapmaprs727479
1000 genomesrs727479
hgdprs727479
ensemblrs727479
gopubmedrs727479
geneviewrs727479
scholarrs727479
googlers727479
pharmgkbrs727479
gwascentralrs727479
openSNPrs727479
23andMers727479
23andMe allrs727479
SNP Nexus

SNPshotrs727479
SNPdbers727479
MSV3drs727479
GWAS Ctlgrs727479
GMAF0.315
Max Magnitude
? (G;G) (G;T) (T;T) 28
[PMID 19124504OA-icon.png] endometrial cancer rs727479(A) odds ratio per allele of 1.08, 95% confidence interval of 1.02-1.14, and P = 0.009


[PMID 19366906] BRCA1 Breast Cancer Risk Is Modified by CYP19 Polymorphisms in Ashkenazi Jews

OMIM107910
DescCYTOCHROME P450, FAMILY 19, SUBFAMILY A, POLYPEPTIDE 1; CYP19A1
Variant
Relatedalso
[PMID 19789370OA-icon.png] CYP19A1 Genetic Variation in Relation to Prostate Cancer Risk and Circulating Sex Hormone Concentrations in Men from the Breast and Prostate Cancer Cohort Consortium

[PMID 16733710OA-icon.png] Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families.

[PMID 16782804OA-icon.png] Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females.

[PMID 17325027] Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.

[PMID 18199708OA-icon.png] Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study.

[PMID 18245543] A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma.

[PMID 18622258OA-icon.png] Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women.

[PMID 18667686OA-icon.png] Association of two common single-nucleotide polymorphisms in the CYP19A1 locus and ovarian cancer risk.

[PMID 18941913OA-icon.png] Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.

[PMID 19015200OA-icon.png] Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.

[PMID 19064562OA-icon.png] Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China.

[PMID 19794821OA-icon.png] Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women.

[PMID 20144226OA-icon.png] A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole.

GWAS snp
PMID [PMID 22675492OA-icon.png]
Trait
Title Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
Risk Allele C
P-val 5E-7
Odds Ratio 0.1070 None


[PMID 23129173OA-icon.png] Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole


[PMID 23700878] Research on aromatase gene (CYP19A1) polymorphisms as a predictor of endocrine therapy effectiveness in breast cancer


[PMID 23669293] CYP19A1 gene polymorphisms and risk of lung cancer.


[PMID 26574572] CYP19A1 fine-mapping and Mendelian randomisation: estradiol is causal for endometrial cancer