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rs727957

From SNPedia

Orientationplus
Stabilizedplus
Make rs727957(G;G)
Make rs727957(G;T)
Make rs727957(T;T)
ReferenceGRCh38 38.1/141
Chromosome21
Position34507774
GeneKCNE1
is asnp
is mentioned by
dbSNPrs727957
ebirs727957
HLIrs727957
Exacrs727957
Varsomers727957
Maprs727957
PheGenIrs727957
hapmaprs727957
1000 genomesrs727957
hgdprs727957
ensemblrs727957
gopubmedrs727957
geneviewrs727957
scholarrs727957
googlers727957
pharmgkbrs727957
gwascentralrs727957
openSNPrs727957
23andMers727957
23andMe allrs727957
SNP Nexus

SNPshotrs727957
SNPdbers727957
MSV3drs727957
GWAS Ctlgrs727957
GMAF0.08127
Max Magnitude
? (G;G) (G;T) (T;T) 28

23andMe blog Influences QT interval


GWAS snp
PMID [PMID 20062063]
Trait Electrocardiographic traits
Title Several common variants modulate heart rate, PR interval and QRS duration
Risk Allele T
P-val 2E-12
Odds Ratio 11.70 [8.46-14.94] % SD increase


[PMID 18674739] Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study.


[PMID 19587794OA-icon.png] Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.


GET Evidence
rs727957
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.117188
summary may influence cardiac repolarization and cardiovascular mortality